The invention relates to a medical PVC material adopted for steam sterilization, and a preparation method thereof. The material comprises, by weight, 100 parts of PVC resin, 40-70 parts of a plasticizer DOP, 1.5-2.0 parts of a calcium/zinc heat stabilizer, 6-10 parts of an assistant heat stabilizer and 1.0-1.5 parts of a lubricant. The PVC resin is the polyvinyl chloride resin prepared through a suspension method, and has a polymerization degree of 1000-1300. The calcium/zinc heat stabilizer is a composite, wherein the composite comprises, by weight, 40-60% of calcium stearate, 20-30% of zincpalmitate, 15-30% of hydroxy magnesium/aluminum. The assistant heat stabilizer is epoxidised soyabean oil. The lubricant comprises, by weight, 55-60% of silicone oil and 40-45%of oxidized polyethylene wax. In the prior art, the PVC material is sterilized through the steam sterilization method, the high temperature (121 DEG C) and the long time treatment (30 minutes) during the steam sterilization process can cause degradation and yellowing of the PVC material, the precipitation of the plasticizer can cause clamminess generation of the instrument surface. With the present invention, the problems in the prior art are solved, the heat resistance of the medical PVC material is improved, and the probabilities of the yellowing and the precipitation of the plasticizer after steam sterilization are reduced.