The utility model belongs to the technical field of clamps, and particularly relates to a sample clamp capable of adjusting the clamping direction, which comprises a lower base, an adjusting screw rod is arranged on the inner wall of the lower base, a sliding block is in threaded connection with the outer wall of the adjusting screw rod, and two ends of the sliding block are movably connected with connecting pore plates. The top end of the connecting hole plate is fixedly connected with an adjusting seat rotationally connected with the inner wall of the lower base, the adjusting seat and a clamping block are arranged, an adjusting screw rotates to drive a sliding block to slide through threads, the sliding block slides to drive the adjusting seat to rotate through the connecting hole plate, and then the adjusting seat rotates to drive the clamping block at the top end of the clamping frame to rotate synchronously. The clamping direction of the clamping block is adjusted, a sample can be stably clamped according to the shape of the sample, then the connecting groove moves to drive the connecting base to slide in the limiting groove, the connecting base slides to drive the clamping block to clamp the sample, and similarly, the top end of the sample is clamped through the upper base.