The invention relates to a sequence 
radial basis function agent model-based high-efficiency 
global optimization method, and belongs to the technical field of multidisciplinary optimization in 
engineering design. The method comprises the following steps of: according to initial conditions given by a user, selecting sample points in a primary iteration 
design space, calculating a response value of a true model, constructing a 
radial basis function agent model, calculating the current optimal solution of the 
radial basis function (RBF) agent model, calculating a response value of the possible optimal solution of the current iteration in the true model, judging whether the 
global optimization method meets the convergence criterion, determining an important sampling space of the next iteration, increasing new sample points in the constructed important sampling space by an experimental design calculation method, saving the new sample points in a design sample point 
database and making k equal to k+1, and switching to the constructed radial 
basis function agent model for the next iteration. Through the method, the true models in the 
engineering design and 
analysis software are approximated, and the optimization design of the true models only takes several or dozens of seconds, so the period of the 
engineering optimization design is greatly shortened, the design cost is greatly saved and the efficiency is obviously improved.