The invention relates to a multistage cyclic code shift keying modulation and demodulation method based on transform domain communication, and belongs to the field of wireless digital communication. The method comprises the steps that a transmitting end generates a normalized frequency-domain basis function, carries out inverse Fourier transform on the normalized frequency-domain basis function to generate a time-domain basis function, generates MCCSK sub-symbols according to the time-domain basis function, and transmits the sub-symbols after carrying out data modulation through the sub-symbols; a receiving end generates a time-domain basis function corresponding to the transmitting end, and carries out MCCSK data demodulation according to the time-domain basis function to obtain demodulated data. According to the method, the diversity of modulation symbols is improved through the combinatorial number method, the symbols generated by cyclic code shift of the basis function are superposed and combined to generate more expanded symbols, symbols with the large minimum average symbol space are selected to be combined and used for modulation, the data are demodulated at the demodulation end in a multistage demodulation mode, and therefore the quantity of information carried by a unit waveform is increased, and the bit error rate loss is effectively controlled.