The invention relates to the field of artificial intelligence, and discloses a cup-to-disk ratio determination method, device and equipment, and a storage medium. The method comprises the following steps: obtaining and detecting an eye fundus image, and obtaining an optic disk region; inputting the optic disk region into a coding network of an image segmentation model, and extracting image features to obtain a first feature map; inputting the first feature map into a position correction network of the decoding network to obtain a position-corrected second feature map; performing convolution operation on the first feature map through a segmentation network in the decoding network to obtain a third feature map; splicing the second feature map and the third feature map through a connection layer to obtain an image segmentation result; according to an image segmentation result, calculating to obtain an optic cup diameter and an optic disc diameter; and calculating the cup-to-disc ratio of the fundus image according to the optic cup diameter and the optic disc diameter. According to the method, the accuracy of the optic cup and optic disc image obtained through segmentation is improved, multi-screening and screening missing conditions in the disease screening process are reduced, in addition, the invention further relates to a block chain technology, and the eye fundus image can be stored in a block chain.