The invention discloses a biopsy sampler for the digestive system department, and the biopsy sampler comprises a puncture mechanism which is used for penetrating into a focus; a shell, wherein one end of the shell is connected with the puncturing mechanism, a sampling groove is formed in the shell, and the sampling groove is located beside the puncturing mechanism; a sampling mechanism which comprises a push rod, a moving seat, a scraping piece and a bearing groove body, wherein the moving seat is installed in the shell, the moving seat can move in the direction away from or close to the puncture mechanism under guiding of the shell, the push rod penetrates through the moving seat, the push rod can only rotate relative to the moving seat, and the bearing groove body is installed at the end, close to the sampling groove, of the push rod, the receiving groove body is used for receiving a sampling object through the sampling groove, and an elastic scraping sheet is mounted at the receiving groove body; and a first elastic mechanism which is installed between the moving seats, wherein the first elastic mechanism is used for keeping the bearing groove body blocked by the shell. The biopsy sampler for the digestive system department solves the problem that in the prior art, non-fluid tissue at a focus is difficult to enter a sampling groove.