The invention relates to an air-conditioning system with independent control of temperature and humidity, which includes a high-temperature chiller, a chilled water pump, an indoor sensible heat terminal device, an air precooling module, a solution dehumidification unit, and a solution regeneration unit; Connect the inlet of the indoor sensible heat terminal device, air pre-cooling module and solution dehumidification processing unit, and connect the outlets of the indoor sensible heat terminal device, air pre-cooling module and solution dehumidification processing unit back to the high-temperature chiller to form a loop; use the high-temperature chiller to generate Part of the high-temperature cold water is passed into the indoor sensible heat terminal device to undertake the task of indoor temperature regulation, part of the high-temperature cold water is passed into the air pre-cooling module to pre-cool the fresh air, and part of the high-temperature cold water is passed into the solution dehumidification processing unit to perform the circulating spray solution cool down. The invention can independently adjust the indoor temperature and humidity, maximize the energy efficiency advantage of the high-temperature cold source, better meet the indoor temperature and humidity adjustment requirements, and realize the efficient operation of the air-conditioning system.