The invention relates to an aseptic cotton bud used for medical apparatus and instruments. The aseptic cotton bud is composed of a cotton bud rod, a hand-held handle and a bud head, wherein the head end of the cotton bud rod is pinpoint-shaped, the tail end of the cotton bud rod is connected with the hand-held handle, the length of the cotton bud rod is 5-6 cm, the diameter of the cotton bud rod is 1mm, the length of the head end of the cotton bud rod is 0.5-0.6 mm, the included angle alpha between the inclined surface of the head end of the cotton bud rod and the axis of the cotton bud rod is 30-45 degrees, the diameter of the hand-held handle is greater than that of the cotton bud rod, and the bud head tightly wraps the periphery of the head end of the cotton bud rod. The head end of the aseptic cotton bud is sharp, thus being capable of easily penetrating the structure such as a groove for cleaning dirt and cleaning the blood scab on a threaded hole, the shortened cotton bud rod enables the aseptic cotton bud to have the small possibility of breaking off, the thickened hand-held handle is convenient to hold, and the medical apparatus and instruments, such as the intravenous catheter, needing long-time indwelling can be completely cleaned and disinfected easily, the residue of dust, dirt and bloodstain is avoided, and the occurrence of adverse events such as catheter infection is reduced.