The invention belongs to the field of security and protection devices, particularly relates to an intelligent anti-disassembly Internet-of-Things security and protection device, and aims to solve theproblem that most of existing security and protection equipment is mounted and fixed in a bolt mode and is easily maliciously disassembled by lawless persons, the intelligent anti-disassembly Internet-of-Things security and protection device comprises a protection box, an opening is arranged at one side of the protection box, a monitoring device is arranged in the protection box, a cover plate isinstalled on one side of the protection box, a through hole is formed in the cover plate, one end of the monitoring device penetrates through the through hole, two inserting grooves are formed in oneside of the protection box, inserting plates are clamped in the two inserting grooves, and one sides of the two inserting plates are fixedly connected with one side of the cover plate. Locking groovesare formed in the sides, close to each other, of the two inserting plates correspondingly, locking plates are clamped in the two locking grooves correspondingly, connecting plates are fixedly installed on the sides, close to each other, of the two locking plates correspondingly, and the monitoring device is located between the two connecting plates. The device has an alarm function, can effectively prevent malicious disassembly, and is simple in structure and convenient to use.