The invention discloses a method for calculating the radiation noise generated by the pipe wall of a water-filling pipeline during the reverberation method. According to the method, firstly, the radiation noise and the jet noise, generated due to the vibration of the pipe wall of a water-filling pipeline, are measured based on the reverberation method. Secondly, only the jet noise of the water-filling pipeline is measured and obtained based on the reverberation method, so that the radiation noise of the underwater water-filling pipeline generated during the vibration process is obtained. The above method is simple in calculation and high in efficiency. The radiation noise and the jet noise, generated by the pipe wall of the water-filling pipeline in a single non-noise-elimination pool and measured based on the reverberation method, is subtracted by the jet noise of the water-filling pipeline measured based on the reverberation method. In this way, the radiation noise of the water-filling pipeline generated during the vibration process is obtained.