The invention provides a control device of a circuit system. The control device comprises a main power supply circuit, a main controller circuit, a switch driving circuit, a switch module, a wake-up circuit and a non-wake-up circuit, wherein the main power supply circuit is respectively connected with the main controller circuit, the switch driving circuit and the wake-up circuit, the main power supply circuit is also connected with the non-wake-up circuit through the switch module, and when a circuit system enters a low-power-consumption state, the main controller circuit sends a control signal to the switch driving circuit, the switch driving circuit controls the switch module to be switched off according to the control signal, and the main power supply circuit stops supplying power to the non-wake-up circuit. The invention further provides a control method of the circuit system. According to the control device and method of the circuit system, when the circuit system enters the low-power-consumption state, the non-wake-up circuit is completely powered off to achieve zero power consumption of the circuit, and the devices and chips of the non-wake-up circuit do not need to be selected from devices and chips in a sleep mode, so that the system cost is lower.