The invention relates to a safe and reliable three-dimensional parking device convenient to operate. The safe and reliable three-dimensional parking device convenient to operate comprises a base, a top plate, a lifting mechanism, a controller and two parking mechanisms; each parking mechanism comprises a plurality of parking assemblies; the lifting mechanism comprises a first motor, a first bevelgear, a supporting plate, a bottom plate, four lifting assemblies and four protective assemblies; each parking assembly comprises a vehicle-carrying plate, an adjusting assembly, an adjusting plate, atelescopic assembly, a moving plate, a pulling hook and a parking unit; and each parking unit comprises a flat plate, a pulling ring, a first side plate, a second side plate and a closing assembly. According to the safe and reliable three-dimensional parking device convenient to operate, the lifting mechanism drives the bottom plate to rise and fall, thus the parking units are conveniently movedto the same height with the vehicle-carrying plates, then parking is conducted, and more than that, in the parking mechanisms, through cooperative running of the telescopic assemblies and the adjusting assemblies, the parking units can be driven to move onto the vehicle-carrying plates for parking, and can also move onto the supporting plates for convenient vehicle picking-up, so that vehicle parking and picking-up are convenient and quick, and the practicality of the safe and reliable three-dimensional parking device is improved.