The invention relates to a high-power 2450MHz solid-state-source microwave therapy apparatus. The microwave therapy apparatus is composed of a crystal oscillation phase-locked microwave oscillator, a solid-state amplifier, a circulator, a microwave power switch, an embedded microprocessor, a liquid crystal touch screen, a power supply and the like. The microwave therapy apparatus is provided with pulse modulation frequencies of 1Hz, 5Hz, 10Hz and 100Hz except the operating frequency of 2450MHz, output waves comprise continuous waves and four frequency pulse modulating waves, microwave output can be one-way or two-way, and therapy time can be switched automatically as required. The microwave therapy apparatus can be applied to tumor microwave ablation, microwave palliative treatment, microwave operation, microwave physiotherapy and the like. As a new generation of the existing 2450MHz magnetron microwave therapy apparatus, the microwave therapy apparatus has the advantages of being good in safety performance, low in power consumption, long in service life, high in output power, high in power stability and the like.