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12 results about "ASK1" patented technology
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Apoptosis signal-regulating kinase 1 (ASK1) also known as mitogen-activated protein kinase kinase kinase 5 (MAP3K5) is a member of MAP kinase kinase kinase family and as such a part of mitogen-activated protein kinase pathway. It activates c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases in a Raf-independent fashion in response to an array of stresses such as oxidative stress, endoplasmic reticulum stress and calcium influx. ASK1 has been found to be involved in cancer, diabetes, rheumatoid arthritis, cardiovascular and neurodegenerative diseases.
ASK1 inhibitor and application thereof
The invention belongs to the technical field of medicines, and particularly relates to a group of ASK1 inhibitors and application thereof. An ASK1 target spot is related to a plurality of diseases, and in numerous disclosed ASK1 modulators, no marketed medicine exists at present, so that the finding of a more potential ASK1 inhibitor has clinical and scientific significance. The ASK1 small-molecule inhibitor provided by the invention has the advantages of novel structure, good activity and the like, and has the potential of further development.
Owner:CHINA PHARM UNIV
Use of substances inhibiting the nitration of trx1 for the preparation of a medicament for the treatment of associated diseases
This invention discloses the application of substances that inhibit Trx1 nitration in the preparation of drugs for treating Trx1 nitration-related diseases. This invention reveals for the first time that nitration modification of tyrosine residue 49 (Y49) of the Trx1 protein is a key pathological step in diseases such as ischemic stroke and myocardial ischemia-reperfusion injury. Inhibiting nitration at this site can effectively restore Trx1 reductase activity, enhance the binding of Trx1 to ASK1, and block the downstream ASK1-p38 / JNK apoptosis signaling pathway, thereby exerting a therapeutic effect. This invention provides a novel treatment strategy for Trx1 nitration-related diseases.
Owner:CAPITAL UNIVERSITY OF MEDICAL SCIENCES
Triazole compound having novel ring structure, method for preparing same, and use thereof
PendingCN122003408Aimprove survival ratesuppress deathOrganic active ingredientsNervous disorderImmunologic disordersNeurophysins
The present invention relates to a triazole compound having a novel ring structure, a preparation method therefor, and a use thereof. The triazole compound having a novel ring structure according to the present invention exhibits excellent ASK1 inhibiting ability and inhibits apoptosis of neurons, and thus can be used for the prevention or treatment of ASK1-related diseases, including neurodegenerative diseases, cardiovascular diseases, autoimmune diseases, and liver diseases.
Owner:KOREA RES INST OF CHEM TECH
Tricyclic ask1 inhibitors
Owner:TERNS INC
Aromatic heterocyclic amide compounds and uses thereof
The present invention provides aromatic heterocyclic amide compounds and uses thereof. Specifically, such compounds can effectively inhibit ASK1 kinase activity. They are compounds represented by formulas (I) to (III), or tautomers, stereoisomers, hydrates, solvates, pharmaceutically acceptable salts, or prodrugs of the compounds represented by formulas (I) to (III): #imgabs0#
Owner:WUHAN HUMANWELL INNOVATIVE DRUG RES & DEV CENT LTD CO +1
ASK1 inhibiting agents
Provided are compounds of Formula (I):including compounds of Formulas (II), (III) and (IV), wherein X, R1, R2, R3 and n are as defined herein, and pharmaceutically acceptable salts thereof, and methods for their use and production. These compounds can be useful, e.g., in the treatment of disorders responsive to the inhibition of apoptosis signal-regulating kinase 1 (ASK1).
Owner:BIOGEN MA INC
Tricyclic ask1 inhibitors
Owner:TERNS INC
Triazole compound having novel ring structure, method for preparing same, and use thereof
The present disclosure relates to a triazole compound having a novel ring structure; a method for preparing same; and a use thereof. The triazole compound having a novel ring structure according to the present disclosure exhibits an excellent ability to inhibit ASK1 and inhibits the apoptosis of neurons and thus can be used for preventing or treating ASK1-related diseases including neurodegenerative diseases, cardiovascular diseases, autoimmune diseases, and liver diseases.
Owner:KOREA RES INST OF CHEM TECH
Method of treating liver diseases or disorders with ask1 inhibitors
PCT designated stageWO2026085128A1Digestive systemHeterocyclic compound active ingredientsDiseasePharmaceutical medicine
Provided herein are methods of treating liver diseases and disorders comprising administering to the subject a therapeutically effective amount of Compound A, or a pharmaceutically acceptable salt or solvate thereof.
Owner:SEAL ROCK THERAPEUTICS INC
Methods of treating organ diseases or disorders with ASK1 inhibitors
The present invention relates to the use of Apoptosis Signal-Regulating Kinase-1 (ASK-1) inhibitor compounds for the treatment of diseases and disorders of an organ, wherein the disease or disorder of the organ is selected from diseases or disorders of the liver, heart, kidney, pancreas, spleen, or skin.
Owner:SEAL ROCK THERAPEUTICS INC
Synthesis and application of small molecule compounds with 2-pyridine-substituted carboxamide structures
The present invention relates to a class of small molecule inhibitors of ASK1 kinase, and specifically to the synthesis and application of a small molecule compound having a 2-pyridine-substituted carboxamide structure, as well as a pharmaceutical composition thereof and its use in preparing ASK1 small molecule inhibitors, or in drugs for preventing and / or treating ASK1-related diseases, especially liver diseases, lung diseases, tumors, cardiovascular diseases, kidney diseases and metabolic diseases.
Owner:JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE