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Apoptosis signal-regulating kinase 1 (ASK1) also known as mitogen-activated protein kinase kinase kinase 5 (MAP3K5) is a member of MAP kinase kinase kinase family and as such a part of mitogen-activated protein kinase pathway. It activates c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases in a Raf-independent fashion in response to an array of stresses such as oxidative stress, endoplasmic reticulum stress and calcium influx. ASK1 has been found to be involved in cancer, diabetes, rheumatoid arthritis, cardiovascular and neurodegenerative diseases.
Use of substances inhibiting the nitration of trx1 for the preparation of a medicament for the treatment of associated diseases
This invention discloses the application of substances that inhibit Trx1 nitration in the preparation of drugs for treating Trx1 nitration-related diseases. This invention reveals for the first time that nitration modification of tyrosine residue 49 (Y49) of the Trx1 protein is a key pathological step in diseases such as ischemic stroke and myocardial ischemia-reperfusion injury. Inhibiting nitration at this site can effectively restore Trx1 reductase activity, enhance the binding of Trx1 to ASK1, and block the downstream ASK1-p38 / JNK apoptosis signaling pathway, thereby exerting a therapeutic effect. This invention provides a novel treatment strategy for Trx1 nitration-related diseases.
Owner:CAPITAL UNIVERSITY OF MEDICAL SCIENCES
Triazole compound having novel ring structure, method for preparing same, and use thereof
PendingCN122003408Aimprove survival ratesuppress deathOrganic active ingredientsNervous disorderImmunologic disordersNeurophysins
The present invention relates to a triazole compound having a novel ring structure, a preparation method therefor, and a use thereof. The triazole compound having a novel ring structure according to the present invention exhibits excellent ASK1 inhibiting ability and inhibits apoptosis of neurons, and thus can be used for the prevention or treatment of ASK1-related diseases, including neurodegenerative diseases, cardiovascular diseases, autoimmune diseases, and liver diseases.
Owner:KOREA RES INST OF CHEM TECH
Triazole compound having novel ring structure, method for preparing same, and use thereof
The present disclosure relates to a triazole compound having a novel ring structure; a method for preparing same; and a use thereof. The triazole compound having a novel ring structure according to the present disclosure exhibits an excellent ability to inhibit ASK1 and inhibits the apoptosis of neurons and thus can be used for preventing or treating ASK1-related diseases including neurodegenerative diseases, cardiovascular diseases, autoimmune diseases, and liver diseases.
Owner:KOREA RES INST OF CHEM TECH
Method of treating liver diseases or disorders with ask1 inhibitors
PCT designated stageWO2026085128A1Digestive systemHeterocyclic compound active ingredientsDiseasePharmaceutical medicine
Provided herein are methods of treating liver diseases and disorders comprising administering to the subject a therapeutically effective amount of Compound A, or a pharmaceutically acceptable salt or solvate thereof.
Owner:SEAL ROCK THERAPEUTICS INC