The invention provides a method, a device, equipment and a medium for positioning far-end interference, and the method comprises the steps: obtaining an unknown adjacent cell, the distance between which and a base station is greater than a preset threshold value, according to an ANR (Automatic Neighbor Relation) process under the condition that a far-end interference characteristic signal is detected; and executing a process of performing remote interference management RIM on the unknown neighbor cell. According to the scheme of the invention, the automatic neighbor relation ANR process is added before the remote interference management RIM process is executed, the unknown neighbor of which the distance to the base station is greater than the preset threshold value is obtained, the remote interference caused by the atmospheric waveguide is discovered and positioned in an assisted manner, the number of the base stations for monitoring and sending the configuration reference signal RS managed by the OAM system is reduced, and the monitoring efficiency of the remote interference caused by the atmospheric waveguide is improved. The management overhead of the OAM system can be saved, and the power consumption of the base station can be reduced.