93 results about "Biologic treatment" patented technology

The invention provides methods and compositions for the treatment of a skin disorder associated with detrimental TNFα activity, such as psoriasis. The invention includes methods for treating a skin disorder associated with detrimental TNFα activity, such as psoriasis, in a subject who has failed or lost response to prior biologic therapy, such as prior administration of etanercept. The invention further provides methods for determining the efficacy of a human TNFα antibody, or antigen-binding portion thereof, for the treatment of a skin disorder associated with detrimental TNFα activity, such as psoriasis.

The present invention provides a composition having disinfectancy & residual antimicrobial activity, where the antimicrobial composition comprises an organosilane quaternary compound and a quaternary ammonium compound and other formulations. Also provided are methods of disinfecting an article or providing an antimicrobial coating to an article using the same.

/Composition and methods for the prevention and treatment of hypercholesterolemia, hyperlipidemia and atherosclerosis are described. Individuals at a high risk of developing or having hypercholesterolemia and atherosclerosis undergoing conventional therapies may be treated with an effective dose of triperpene derivatives in limonoids, polyphenolic flavonoid compounds, tocotrienols or a combination of these agents.

Compositions and methods for using nordihydroguaiaretic acid (NDGA) derivatives for preventing the expression of MDR-1 gene and the synthesis of PgP protein or reversing multiple drug resistance in cells, and for using NDGA derivatives in combination with additional chemotherapeutic agents to treat drug resistant cancer and infections.

The invention discloses a method for supercritical CO2 extraction of effective ingredients of Haematococcus pluvialis spore powder, comprising the steps of: carrying out liquid-nitrogen low-temperature grinding physical wall breaking, granulation, infiltrate and other biological treatments on Haematococcus pluvialis spore powder according to the characteristic that the structure of astaxanthin in Haematococcus pluvialis is mainly 3S-3'S type, carrying out extraction separation with supercritical CO2 fluid, collecting astaxanthin extract by adjusting the temperature, pressure and flow of the fluid as well as extraction time in the extraction separation process, and carrying out saponification and liquid chromatography separation and purification to prepare high-grade astaxanthin, wherein the conversion rate of astaxanthin achieves about 90% and the extraction rate of astaxanthin is greatly increased.

The invention discloses a chemical depth treatment method applied to antibiotic wastewater treatment. The method comprises the following steps: (1) enabling effluent subjected to biologic treatment to enter a four-phase catalysis oxidation device with an alloy catalyst, feeding a catalyst and an oxidant, generating hydroxyl radical OH, and performing blowing and aerating; (2) enabling the effluent subjected to reaction to enter an oxidation reaction tank, and continuously carrying out oxidation reaction through micro-pore aeration so as to form a great deal of tawny floccule; (3) feeding 30% of an alkali liquid into a mixture liquid, regulating the pH value of the mixture solution to be neutral, further feeding a coagulant PAC (Poly Aluminum Chloride) and a macromolecule coagulant aid PAM (Polyacrylamide), baffling and collecting the floccule, and enabling the sludge to enter a concentration tank treatment system. The method is simple to operate, low in operation cost and good in elimination effect, thorough elimination of nondegradable COD (Chemical Oxygen Demand), chromaticity and impurities which cannot be degraded through high-efficiency microbiological treatment can be ensured through biologic treatment, and final up-to-standard emission of high-difficulty wastewater of antibiotics can be achieved.

The method uses the anaerobic glove case and many modified culture medium to screen the anaerobic bacteria which possesses the highly effective character of degrading chlorophenol and acid resistance. The method comprises the following steps: A. screening the anaerobic particle sludge; B. segregation and purifying bacteria; C. primary screening the anaerobic bacteria degrading chlorophenol; D. second screening: segregation and purifying with the solid-liquid culture medium, until the cell shape being the single thallus. The operation is simple, and the theory meaning and economic value are important. The method provides the theory basis for anaerobic biological treatment process of chlorophenol waste water. The method can be used to separate, screen and culture the chlorophenol degradation bacterium, and provide the good screening method for researching chlorophenol degradation rule and interaction between function bacteria.

The invention relates to a compact supporting filler, which comprises a central rope and a fiber fixed on the central rope, wherein the fiber comprises a plurality of fiber units; each fiber unit is wound on the central rope in a way of forming a spiral layer; and every two adjacent fiber units are connected to form a plurality of spiral layers, and are arranged closely and attached. The spiral structure can effectively improve the water distribution and air distribution performance of the filler, fully increase the transfer rate and utilization rate of oxygen and remarkably better biological treatment effects.

The invention belongs to the technical field of biological treatment and discloses a microorganism composition for degrading acetochlor and/or butachlor and an application of the microorganism composition. The microorganism composition comprises Rhodococcus sp. T3-1, Delftia sp. T3-6 and/or Sphingobium sp. MEA3-1 which are all preserved in China Center for Type Culture Collection on December 15, 2012, wherein preservation numbers of the microorganism strains are respectively CCTCC NO: M2012525, CCTCC NO: M2012526 and CCTCC NO: M2015527. The microorganism composition can be applied in combined degradation of acetochlor and/or butachlor.

The invention discloses a biologic treatment method and a production method of slaughter house sledge and feces. The theory that a great amount of organisms are consumed in the growth process of housefly larva is utilized, substances of grease, protein and the like in the sledge and feces can be effectively degraded, and the purpose of sledge harmlessness is finally achieved. According to the methods, the following raw materials in percentage by weight are mixed up: 30-50% of animal feces, 1-3% of bean pulp, 3-10% of bagasse, 3-8% of distiller grain, 3-5% of wheat bran, 5-10% of cornstalk, 3-10% of housefly egg and the balance of slaughter house sledge. The methods have the characteristics of safety and environment friendliness in a treatment process, high treatment efficiency, low energy consumption in the treatment process, and no waste gases, waste liquids and the like, various wastes can be treated at the same time in the treatment process, the various wastes can be finally converted into biologic organic fertilizers and biologic feed raw materials, industrialization and earning in sledge treatment are facilitated, the production cost of companies is lowered, and comprehensive popularization and wide application are facilitated.

The invention discloses a mixed microbial agent for degrading sulfonamide antibiotics in sewage and a preparation method and application thereof, belonging to the technical field of environmental microorganisms. The mixed microbial agent for degrading sulfonamide antibiotics in sewage is formed by mixing arthrobacter sp. YL1 and pseudomonas sp. YL2 in a volume ratio of 1: (2-3). The mixed microbial agent is used for treating sulfonamide antibiotics in sewage or degrading organic matters in sewage. The arthrobacter sp. YL1 and the pseudomonas sp. YL2 are separated from each other in the invention can use sulfonamide antibiotics as a unique carbon source for growth and can realize rapid and efficient degradation of the sulfonamide antibiotics; and compared with a single strain, the double-strain interaction microbial agent system has higher removal efficiency, more thorough removal amount and a more stable community structure in the process of practical application, and is very criticalto biological treatment of sulfonamide antibiotics in water. The mixed microbial agent of the invention is applied to the field of antibiotic degradation.

The invention relates to a frequency optimal control method for ultrasonic biological treatment. In the method, the ultrasonic biological treatment process is controlled by utilizing a wide-frequency domain ultrasonic power supply device by adopting an operation strategy of multiband sequential search, catching and locking the optimal processing frequency. When the domain ultrasonic power supply device is in running, energy converter vibration boards matched with mid-band frequency are configured in sequence according to the frequency search directions of frequency bands in the working frequency domain of the ultrasonic power supply device; by the coordination and the control (general control, display and operating parameter setting function, a frequency sweep mode and a power given function) of a control terminal, frequency sweep is carried out on upper limit frequency defined frequency bands and lower limit frequency defined frequency bands; the upper limit frequency and the lower limit frequency of each frequency band are manually set or automatically continuously spliced by referring to the natural frequency of the energy converter, and the frequency sweep mode is manually or automatically set.

The invention provides a method for starting an air-liquid two-phase bacterium culture and reaction device for the biologic treatment of waste gas as well as a special bacterium culture device used bythe bacterium culture method. The method comprises the following steps: taking a solution comprising simulated target waste gas or a mixture of the solution and gas as a nutrient source, carrying outdomesticated culture on strains for 5-20 days, spraying mixed bacterium liquid obtained by culture on a biologic filler in a biologic reactor directly and starting the biologic reactor treating the target waste gas quickly; and the special device comprises a bacterium culture tank, a simulated waste gas distribution system, an electric control device, a liquid feeding system of a liquid material,a liquid feeding system of nutritional liquid and a tail gas purification system. The method and the device thereof start the biologic reactor quickly, are effective and stable to remove contaminantsand save the running cost; liquid state substances with the same properties are directly used as a substrate, which can eliminate the difficulty and the unsafe factors of toxic and harmful gas in operation in the strain culture process; the varieties of microorganisms in the cultured mixed bacterium liquid are abundant, and the pertinence is strong; and the device has simple and flexible operation and strong adaptability.

The invention discloses pyrolysis phycophage MACPNOA1 and a separation method and application thereof, and relates to biological treatment of eutrophic water. MACPNOA1 is preserved in China General Microbiological Culture Collection Center in October 24th, 2016, and the preservation number is CGMCC No.12996. MACPNOA1 has a wide alge-lysing spectrum, and widely lyses common water-blooming cyanobacteria; when MACPNOA1 is added into cyanobacterial water-blooming liquid belonging to seven categories of Microcystis, Aphanizomenon, Chroococcus, Planktothrix, Nostoc, Oscillatoria and Anabaena, MACPNOA1 has strong pyrolysis effects on all the measured seven categories. When MACPNOA1 is applied to algal bloom treatment, the obvious effect of protecting animals in water is achieved. The pyrolysis phycophage MACPNOA1 has the advantages of being safe, efficient and quick.

The invention discloses a strain of rhodococcuscercidiphylli and a screening method and application thereof. The technical scheme provided by the invention is that the rhodococcuscercidiphylli is preserved in general microbe center of China Microbiological Culture Collection Preservation Committee with the preservation number of CGMCCNo. 9067. The invention further discloses the screening method of the rhodococcuscercidiphylli and the application of the rhodococcuscercidiphylli in degrading nitrosamines. The screening method of the rhodococcuscercidiphylli, provided by the invention, is simple and fast in operation, and can be applied to drinking water contaminated by nitrosamines for degrading and removing nitrosamines, performing biological treatment on the drinking water contaminated by nitrosamine substances, and reducing risk level.

The invention discloses a floating type lake heavy-metal collecting device and a use method therefor and belongs to the technical field of biological treatment. According to the floating type lake heavy-metal collecting device and the use method therefor, a plurality of substance gathering balls with metal adsorption balls are suspended in water by means of floating, are limited through submarineload-bearing devices and meanwhile are limited through high-strength bridles, so that difficulty in collecting at a later stage caused by water flow followed fluctuation of the substance gathering balls is effectively avoided; meanwhile, the metal adsorption balls are attracted into the substance gathering balls through magnetic attraction and are subjected to centralized magnetic-attraction fixing and stacking, so that the heavy-metal adsorption balls can form an adsorption plane, and thus, the adsorption effect is improved; meanwhile, a reticular upper-hemisphere shell and a lower screen areused for filtering floating matters in the water, so that adsorption saturation of the metal adsorption balls caused by the floating matters and particulate matters is effectively avoided; and aftermetal adsorption is saturated, the metal adsorption balls easily fall into a collecting bag, and thus, subsequent collecting treatment is facilitated.

The present disclosure provides a method for treating and/or preventing nephrotic syndrome, such as but not limited to MCD and MN, and conditions related to nephrotic syndrome, such as but not limited to, proteinuria and edema, as well as diabetic nephropathy, diabetes mellitus, lupus nephritis or primary glomerular disease. The present disclosure further provides methods for reducing proteinuria and other disease states as discussed herein. Such methods comprise the therapeutic delivery of an Angptl4 polypeptide or Angptl4 polypeptide derivative to a subject.

The invention provides a life integration environmentally-friendly facility for field operation. The life integration environmentally-friendly facility for the field operation is provided with basic structures of a tap water pipe, a sewage pipe, a circuit, a toilet, a bathroom or a kitchen and the like. The sewage pipe sequentially comprises a toilet sewage cutting pumping system, a high concentration sewage pool, a low concentration sewage pool, a biologic treatment pool, a disinfection pool, a reclaimed water pool, a reclaimed water pipe, a waste gas pipe and an oil separation slag removal system. Toilet sewage is discharged in the high concentration sewage pool through the toilet sewage cutting pumping system, food waste sewage is discharged in the high concentration sewage pool through the oil separation slag removal system, sewage of the bathroom and a washing machine is discharged in the low concentration sewage pool, the biologic treatment pool comprises a master boot record (MBR) or selective beacon radar (SBR), sewage sludge provides nutrition and moisture of microbial strains, a part of reclaimed water is used for washing the toilet, a part of reclaimed water is used for washing MBR filter membranes in the biologic treatment pool, and the rest water is discharged outside. The life integration environmentally-friendly facility for the field operation can improve living conditions of field operation staff and has functions of full-automatic domestic sewage treatment, water recycling and ecological environmental protection.

Embodiments of the present invention provide an integrated solution to radiotherapy treatment planning that enables accurate recording and accumulation of physical parameters as input (e.g., dose, dose rate, irradiation time per voxel, etc.). User-defined functions are evaluated to correlate the input parameters with 4D biological outcomes. The resulting biological parameters can be visualized as a biological outcome map to evaluate decisions, support decisions, and optimize decisions regarding the parameters of the radiotherapy treatment plan, for example, for supporting clinical trials and related clinical research.

The invention discloses a strain of pseudomonas poae and application thereof to sewage treatment, and relates to the technical field of environmental microorganism and sewage treatment. The pseudomonas poae is named as NL-4; the preservation number is CGMCC (China General Microbiological Culture Collection Center) No.13450. Polyvinyl alcohol and sodium alginate are used for embedding the pseudomonas poae NL-4, and an immobilized carrier of the pseudomonas poae NL-4 can be obtained. The NL-4 and the immobilized carrier can be applied to the sewage treatment. The pseudomonas poae can improve the sewage biologic treatment efficiency under the low-temperature condition; an effective removal effect is achieved on NH3-N, NO3<->-N and COD in sewage; the outlet water standard reaching rate is improved by enriching the quantity and improving the activity of cold-resistant microorganisms in sewage biological treatment buildings. The method has the advantages that the operation is simple; the cost is low; economic performance and environment protection are realized; the pseudomonas poae can be singly used or can be applied to wastewater treatment after the immobilization; the application is wide.

The present invention provides systems, devices, apparatuses and methods for automated bioprocessing. Examples of protocols and bioprocessing procedures suitable for the present invention include but are not limited to: immunoprecipitation, chromatin immunoprecipitation, recombinant protein isolation, nucleic acid separation and isolation, protein labeling, separation and isolation, cell separation and isolation, food safety analysis and automatic bead based separation. In some embodiments, the invention provides automated systems, automated devices, automated cartridges and automated methods of western blot processing. Other embodiments include automated systems, automated devices, automated cartridges and automated methods for separation, preparation and purification of nucleic acids, such as DNA or RNA or fragments thereof, including plasmid DNA, genomic DNA, bacterial DNA, viral DNA and any other DNA, and for automated systems, automated devices, automated cartridges and automated methods for processing, separation and purification of proteins, peptides and the like.

Provided herein are methods for using a thrombin peptide derivative to treat a medulloblastoma. In one embodiment, the method includes administering to a subject having a medulloblastoma an effective amount of a thrombin peptide derivative, and exposing cells of the medulloblastoma of the subject to a cancer treatment after administering the thrombin peptide derivative to the subject. An example of a cancer treatment is radiation therapy. In one embodiment, viability of cells of the medulloblastoma is decreased compared to viability of cells of the medulloblastoma before the administering and the exposing. The cells of the medulloblastoma having decreased viability can be cancer stem cells. In one embodiment, shrinkage of the medulloblastoma in the subject is increased compared to shrinkage of the medulloblastoma before the administering and the exposing.

The invention relates to an antibiotic microbe dreg treatment method which comprises the following steps: mixing meat and bone meal adopted as an additive with antibiotic microbe dregs, and exciting naturally existing microorganisms in the microbe dregs by adjusting the microenvironment of the microbe dregs so as to degrade antibiotics. Compared with traditional physical, chemical and microbiological treatment methods of antibiotics, the method has the characteristics of high remediation efficiency, low cost, strong operability, low environmental risk and the like, has good environmental benefits, social benefits and economic benefits, and provides a new method for simultaneously treating two production byproducts, namely antibiotic microbe shroom dregs and meat and bone meal.