63 results about "Biologic treatment" patented technology

A disposable kit for a bioprocessing system includes a tray having a spine having a first window and a second window, at least one bioprocessing vessel received within the tray, a pinch valve manifold removably received by the spine within the first window, a first tubing segment removably received by the spine within the second window, and a second tubing segment removably received by the spine within the second window.

The present disclosure relates to methods of treating or preventing cancer (e.g., advanced solid cancer) using Compound No. 1: (Compound No. 1) or a pharmaceutically acceptable salt thereof. The present disclosure also relates to pharmaceutical compositions and pharmaceutical kits suitable for the treatment or prevention.

Provided are a household toilet waste treatment system and a method of treating toilet waste using the same, the household toilet waste treatment system comprising a solid-liquid separation toilet, a biological treatment apparatus, a sterilization apparatus, and a combustion apparatus. The combustion apparatus complements a slow biological treatment apparatus to allow continuous treatment of the household toilet waste in a unit space without long-distance piping connections.

The invention discloses high-salt-tolerance arthrobacter vitriomyzae capable of producing protease and application of the arthrobacter vitriomyzae, and belongs to the technical field of environmental microorganisms. The invention provides an arthrobacter pseudomonas A1 which is preserved in the China Center for Type Culture Collection on May 23, 2024, and the preservation number of the arthrobacter pseudomonas A1 is CCTCC (China Center for Type Culture Collection) NO: M 20241041. The arthrobacter sp. Can tolerate the salinity of 8.0%, and can still effectively secrete protease under the stress of high salt. The strain can provide an effective strain resource for strengthening anaerobic biological treatment of high-salt and high-protein wastewater such as kitchen wastewater, so that the treatment cost is remarkably reduced, and the strain has important application value.

The application discloses a high-salt-tolerant protease-producing Arthrobacter protophormiae and application thereof, and belongs to the technical field of environmental microorganisms.The application provides the Arthrobacter protophormiae A1 which is preserved in the China Center for Type Culture Collection on May 23, 2024, and the preservation number is CCTCC NO: M 20241041.The Arthrobacter protophormiae provided by the application can tolerate 8.0% salinity, and can effectively secrete protease under high-salt stress.The bacteria can provide effective strain resources for the anaerobic biological treatment of reinforced kitchen waste and other high-salt high-protein waste water, thereby significantly reducing the treatment cost, and have important application value.

The present invention relates to a method for performing a biological process on a liquid immune cell or an initial cell culture to obtain a treated cell culture, where the treated cell culture is intended for autologous or allogeneic cell therapy, where the biological process is performed on an integrated biological treatment system (1), wherein the biological process comprises a series of treatment steps wherein the treatment steps each comprise at least one operation wherein the biological process system (1) comprises a base structure (3) and a preconfigurable cartridge (4) wherein the biological process system (1) performs the operation of the biological process via interaction of the base structure (3) with the cartridge (4), wherein the cartridge (4) and the base structure (3) comprise a matching standardized interface (6) for interaction of the base structure (3) with a corresponding cartridge (4), wherein the biological process system (1) performs at least two operations of the biological process inside at least two differently preconfigured cartridges (4) by interaction of the base structure (3) with the cartridges (4) via the same base structure interface (7) and / or the same base structure interface (7) and a mating cartridge interface (8).

To provide a biological treatment system, a biological treatment apparatus, a water purification system, a biological treatment method and a water purification method that are excellent in the efficiency and stability of biological treatment.SOLUTION: A biological treatment system comprises: a tank 1 containing a mixture of an object to be biologically treated and microorganisms; a monitoring unit 2 that monitors an index of a microbial concentration of the mixture; an adjustment unit 3 that adjusts the microbial concentration of the mixture; and a control unit 4 that controls the adjustment unit based on monitoring results of the index of the microbial concentration.SELECTED DRAWING: Figure 1

The invention discloses a pharmaceutical wastewater treatment all-in-one machine and a treatment process thereof, and relates to the technical field of wastewater treatment.The pharmaceutical wastewater treatment all-in-one machine comprises a bottom plate, the left side of the upper portion of the bottom plate is fixedly connected with a coagulation reaction assembly through a support, and a precipitation assembly is installed on the right side of the coagulation reaction assembly above the bottom plate through a support; a biological treatment assembly is arranged on the upper surface of the bottom plate on the right side of the precipitation assembly, and at least three groups of deep adsorption assemblies are mounted on the upper surface of the bottom plate on the right side of the biological treatment assembly. The system has the advantages that the occupied area is reduced, complex pipeline connection is not needed, and the system adapts to hospitals, small pharmaceutical enterprises and other limited sites; all the components are sequentially and tightly arranged along the wastewater treatment process, wastewater can directly flow in the equipment, pipeline leakage and secondary pollution are avoided, meanwhile, flow and liquid level synchronous control is achieved through an internal structure, wastewater treated in the previous procedure can directly enter a subsequent unit, and the treatment efficiency is improved.

The application provides an electro-catalysis system applied to an anaerobic biological treatment technology, an electrode assembly and application. The electrode assembly comprises an electrode frame, a plurality of cathode electrode plates and a plurality of anode electrode plates. The cathode electrode plates and the anode electrode plates are fixed on the electrode frame at intervals. A plurality of electro-catalysis fillers are arranged at intervals along the height direction of the cathode electrode plates and the anode electrode plates. The electro-catalysis fillers are made of a plurality of "8" type woven products around a center rope. The "8" type woven product is made of modified carbon fiber filaments and a nylon wire framework. The electro-catalysis filler made of the modified carbon fiber filaments can guarantee the strength of the filler, greatly reduce the use amount of carbon materials, reduce the cost and have good corrosion resistance. Since the carbon fiber material has excellent specific surface area, the amount of microorganisms can be enriched, and the efficiency of electron transfer can be improved. Since the nylon wire framework is adopted for support, the form of the filler is guaranteed, and efficient operation of the electro-catalysis reaction is guaranteed.

The present disclosure relates to a valve block (100) for controlling fluid flow into or out of a solution management system (200) for biological treatment, the valve block being a single unit and comprising: at least one inlet port (10); at least one outlet port (20); and four or more valve sections (30) fluidly connected to the at least one inlet port and the at least one outlet port, each valve section configured to receive a valve element (32) for controlling fluid passing through the valve block; wherein the at least two valve sections are fluidically connected to each other by means of an integrally formed first channel (40), which changes direction twice or more.

A novel portable, and attachable device allows precise positioning of micro-tissues, tumor spheroids, and other biological samples during bioprinting. The device features an interchangeable connector for handling samples of various sizes and uses a manually adjustable pressure system for suction and deposition. A programmable control unit coordinates pressure and positioning based on input commands, enhancing accuracy and consistency in tissue handling. Compatible with multiple bioprinter systems and supporting both manual and automated operation, it streamlines workflows and improves user experience. This device addresses challenges in high-throughput biological positioning, critical for tissue engineering, clinical, pharmaceutical, and research applications. It supports advancements in customized medicine, biological models, and environmental monitoring, meeting the growing demand for precise biologic handling in the multi-billion-dollar bioprinting and biopsy markets. The device offers superior control over tissue biopsy positioning compared to current manual devices reliant on operator skill.

A liquid-actuated pump (100, 200, 300, 400) for a biological treatment system, the pump (100, 200, 300, 400) comprising: a pump chamber (130, 230, 330); a flexible diaphragm (132) configured to form a barrier between a control liquid portion (136) of the pump chamber (130, 230, 330) and a process fluid portion (134) of the pump chamber (130, 230, 330); a process fluid flow path (110, 210, 310) including a process fluid portion (134) of the pump chamber (130, 230, 330); and a control liquid flow path (120, 220) comprising: an inlet (122) to the pump (100, 200, 300, 400); an outlet (124) from the pump (100, 200, 300, 400); and a control liquid portion (136) of the pump chamber (130, 230, 330); wherein the control fluid flow path (120, 220) is configured to contain at least a portion of the control fluid of the trapped volume, and wherein displacement of the control fluid of the trapped volume causes deformation of the flexible diaphragm (132), the deformation of the flexible diaphragm (132) causing movement of the process fluid in the process fluid flow path (110, 210, 310).

The present invention relates to a process for removing active pharmaceutical ingredients (API) from wastewater. Biological treatment and oxidation via ozonation, as well as suspended solids removal, is employed to ultimately reduce the concentration of API to an appropriate or acceptable level.

A bioprocessing system for protein manufacturing from human blood is provided that is compact, integrated and suited for on-demand production and delivery of therapeutic proteins to patients. The patient's own blood can be used as the source of cell extracts for the production of the therapeutic proteins.

A biological treatment system comprising a central control unit (1); at least two biological treatment units (2a, 2b) wherein each of the at least two biological treatment units comprises at least one flow path (3a, 3b) comprising an inlet (4a, 4b) and an outlet (5a, 5b), at least two selected biological treatment units of the at least two biological treatment units are connected in series by a fluid connection (6) of an outlet of an upstream biological treatment unit (2a) of the two selected biological treatment units and an inlet (4b) of a downstream biological treatment unit (2b) of the two selected biological treatment units, therefore, a line of at least two biological treatment units which are connected in series is formed; a client control module (7a, 7b) of each of the at least two biological treatment units, where each client control module is connected to the central control unit, and where each client control module is configured to interact with a biological treatment unit connected to the client control module; and a transfer module (8) associated with each fluid connection (6) between each of said at least two selected biological treatment units in a line of at least two biological treatment units connected in series, wherein each of the transfer modules (8) comprises an upstream set of parameters characterizing an upstream biological treatment unit of each fluid connection (6) and a downstream set of parameters characterizing a downstream biological treatment unit (2b) of each fluid connection, the upstream set of parameters comprising at least an upstream state parameter characterizing a state of the upstream biological treatment unit (2a), and the downstream set of parameters characterizing a state of the downstream biological treatment unit (2b). The downstream parameter set at least comprises downstream state parameters representing the state of the downstream biological treatment unit; and wherein each of the transfer modules (8) comprises at least one algorithm to calculate a decision statement from the upstream and / or downstream set of parameters, wherein the decision statement comprises adjusting a flow rate of a fluid in a fluid connection (6) associated with the transfer module (8).

The utility model provides a gas circuit assembly, an alternate tangential flow device and a perfusion system, and relates to the technical field of biological treatment and pharmacy, the gas circuit assembly provided by the utility model comprises a negative pressure container, a control device, a first vacuum pump and at least one second vacuum pump, the negative pressure container is provided with a negative pressure output pipeline; the first vacuum pump and the at least one second vacuum pump are in fluid communication with the negative pressure container through gas pipelines; and the control device is connected with the negative pressure container and controls the at least one second vacuum pump to start when the internal pressure of the negative pressure container exceeds a preset value. The negative pressure state in the negative pressure container can be ensured to be stable and continuous when the power of the first vacuum pump is insufficient or the first vacuum pump is shut down due to failure, the negative pressure suction device is particularly suitable for providing negative pressure suction for a plurality of ATF system assemblies, and the reliability of the alternate tangential flow device can be improved.

A method of treating a psoriasis plaque subject who has previously been treated with a biological agent, comprising administering to the subject an effective amount of an anti-IL-23p19 subunit antibody, and to the use of an anti-IL-23p19 antibody to treat a psoriasis plaque subject who has previously been treated with a biological agent.

The disclosed technology provides an alternative means of efficient sterilization when transferring sterile media or axenic culture, or when sterilizing media for a bioprocess. Some variations provide a process interconnection comprising: a first process valve; a second process valve in flow communication with the first process valve; a process chamber in flow communication, and interposed between, the first and second process valves; and one or more UV light sources configured to expose ultraviolet light to at least 99% of chamber internal surface area and to at least 99% of valve internal surface area. Some variations provide a system for bioprocessing that utilizes the process interconnection. Other variations provide a system for sterilizing bioprocessing media. Various methods of using the disclosed systems are also disclosed in detail. These include methods of sterile material transfer, methods of axenic culture transfer, methods of sterile bioprocessing, and methods of sterilizing bioprocessing media.

The invention provides an agrobacterium, a screening method and application thereof and a biological preparation, and relates to the field of microorganisms, the agrobacterium is named as agrobacterium CHJ606, the preservation number is CCTCC NO: M202330, and the preservation time is March 15, 2023. The technical scheme of the invention provides the agrobacterium CHJ606, and the strain can degrade the 2, 4-di-tert-butylphenol through a biological treatment method, so that the content of the 2, 4-di-tert-butylphenol as an antioxidant in plastics and other chemical products in the environment is reduced, and the adverse influence of the 2, 4-di-tert-butylphenol on the environment and organisms is reduced.

The invention relates to a method for performing a bioprocess on immune or naive cell culture(s) to obtain processed cell culture(s) on a semi-automated bioprocessing system (1), comprising a primary workstation (2) and performing a workflow, the workflow comprising a plurality of unit operations performed by the primary workstation (2), wherein the primary workstation (2) comprises a unit operation interface (4), wherein the unit operations are performed by an interaction of the unit operation interface (4) with at least one cartridge (5), wherein a first unit operation (16) and a second unit operation (17) of the plurality of unit operations are performed by the unit operation interface (4) with different cartridge configurations (13), wherein between the first and the second unit operation (16, 17) the cartridge configuration (13) is manually reconfigured in a reconfiguration step, wherein the manual reconfiguration in the reconfiguration step is supported by the bioprocessing system (1).

The present invention relates to an integrated bioprocessing system for performing several bioprocesses on a liquid immunocellular cell culture or naive cell culture, wherein the integrated bioprocessing system (1) performs several different bioprocesses by following different protocols, the protocols defining the actions that the integrated bioprocessing system (1) performs on the cell culture for each bioprocess, the integrated bioprocessing system (1) detects at least one state of the cell culture via a sensor (6), the protocols defining the reactions performed by the integrated bioprocessing system (1) when the state of the cell culture deviates from the normal state defined in the protocol, and the integrated bioprocessing system (1) detects at least one state of the integrated bioprocessing system (1), particularly via a sensor (6). It is proposed that the protocols define the reactions performed by the integrated bioprocessing system (1) when the state of the integrated bioprocessing system (1) deviates from the normal state defined in the protocol.

A sprinkler assembly (100) for a biological treatment system (10) includes a base (126) and a plurality of sprinklers (130) connected to the base, each sprinkler including a plurality of apertures, the plurality of sprinklers each having a generally cylindrical shape. Each of the plurality of sprayers includes a side wall and a top defining a cylindrical shape, the side wall and the top each including a plurality of apertures. The apertures of the sidewall may be arranged at a range of heights around a circumference of the sidewall. The ridges may also be located on the sidewalls over the respective array of holes.

A closure system (100) for mixed fluids for use in a biological treatment system comprises automated means for operating a tube weld (160) between a first tube fluidly connected to a first consumable (10-1) and another tube fluidly connected to a mixed consumable (10-3), the pipe weld forms a closed fluid connection between the first consumable and the mixed consumable; an automated device for delivering a first fluid contained in the first consumable to the mixed consumable via a fluid connection; and an automated device for determining the amount of fluid delivered to or from the mixed consumable; wherein the system is further configured to operate a tube weld between a second tube fluidly connected to the second consumable (10-2) and another tube fluidly connected to the mixed consumable, and to deliver a second fluid between the second tube and the another tube to mix with the first fluid in the mixed consumable.

A system includes a plate, a robotic arm, a gripper, and a plate holder. The plate includes a plurality of sides, a bottom surface, and a top surface. The gripper is coupled to the robotic arm and supports the plate from below. The gripper includes gripper arms and the gripper arms are inserted below the plate from opposite lateral directions. The plate holder is sized and shaped to support the plate. The plate holder includes a recessed edge that allows the gripper arm to sufficiently access opposing sides of the plurality of sides of the plate and a portion of the bottom surface of the plate adjacent the opposing sides of the plate. The plate holder includes an alignment guide configured to align the plate with a predetermined position on the plate holder.

A biological treatment system for performing a biomanufacturing process is provided. In one embodiment, a system includes a single-use bag configured to perform a biological treatment operation using at least one port welded to the single-use bag. The at least one port has a channel for providing a fluid pathway to an interior volume of the disposable bag. The system also includes at least one mating ring. The at least one port includes a first feature configured to engage with a corresponding second feature of the at least one mating ring such that the at least one mating ring can be locked to the at least one port. The mating rings and bag ports are configured to provide a range of structural functionalities to facilitate assembly and use of the biological treatment system.

The utility model relates to the technical field of tail water treatment, and discloses a biological treatment device for breeding tail water, which comprises a water pipe and an aeration tank, one end of the water inlet pipe is fixedly connected with a grit chamber, the inner wall of the grit chamber is fixedly connected with a liquid flowing plate, the outer wall of the grit chamber is fixedly connected with a drain pipe, one end of the drain pipe is provided with an oxygen supply component, and the other end of the drain pipe is provided with a water outlet. A one-way valve assembly is arranged on the outer wall of the aeration tank; the one-way valve assembly comprises a fourth connecting pipe, the side wall of the fourth connecting pipe is fixedly connected to the outer wall of the aeration tank, one end of the fourth connecting pipe is fixedly connected with an annular column, and the inner wall of the annular column is fixedly connected with a fixing plate. According to the biological treatment device, the fixing column is driven by the sealing plug to move, the spring on the outer wall is contracted by the fixing column, and the fixing column slides in the lantern ring, so that the effect of a one-way valve is achieved, the problem that when the device is stopped due to the absence of the one-way valve, liquid flows back and is mixed is solved, and the stability of the biological treatment device is improved.

The invention relates to a low-salt-content polypeptide production method, and belongs to the technical field of polypeptide production. The method comprises the following steps: removing surface meat and grease from cattle bones, sheep bones and pig bones, cleaning, carrying out multi-stage crushing to prepare crushed bones, soaking the crushed bones in a microbial bacteria solution to play a biological treatment role, further adding acid, citric acid, acetic acid and hydrochloric acid with different strengths, carrying out gradient acid pickling, and finally carrying out protease enzymolysis to obtain the high-protein protein powder. And performing spray drying to obtain a finished product of the low-salt-content polypeptide. The low-salt-content polypeptide obtained through recycling of the soup, microbiological treatment, multi-stage pickling and mild enzymolysis is high in quality, low in salt content and sufficient in extraction.

A biological treatment system comprising: a treatment vessel; a plurality of filter housings; a feed pump for moving fluid between the processing vessel and the filtration assembly; and a retention valve within the retention line. The retention valve includes a fluid passage to selectively direct movement of a fluid to at least one of the plurality of filter housings; an osmotic valve is arranged in the osmotic pipeline between the filter shell and the osmotic pump; a pressure sensor disposed in the permeate line, and a controller coupled to the pressure sensor, the retention valve, and the permeate valve. A controller actuates the retention valve and the osmotic valve to direct flow between the processing vessel and the one or more filter housings based on information received from the flow sensor and the pressure sensor, and direct osmotic flow from the filter housings to the osmotic pump.

A preparation kit and method for reconstituting and delivering biologic treatments derived from human umbilical cord and amniotic membrane tissue. The kit includes a vial containing lyophilized biologic material, a removable seal, and a spray nozzle with a removable cap to maintain sterility. A container holds a humectant solution comprising glycerol, hyaluronic acid, or a combination thereof. In use, the humectant solution is added to the vial, the biologic material is mixed, and the spray nozzle is used for aesthetic application to human skin or hair. The vial is made of glass or medical-grade plastic to prevent contamination. The spray nozzle delivers a measured dose ranging from 0.5 mL to 5 mL. The method involves removing the seal, adding the humectant solution, attaching the spray nozzle, mixing the components, and applying the biologic via spray.

Method for performing a bioprocess on liquid immune cell cultures comprising a sequence of processing steps, wherein the bioprocess is being performed on an integrated bioprocessing system, wherein the sequence of processing steps comprises at least one unit operation, which is being performed within a unit operation station of the integrated bioprocessing system. Cartridges, that have been preconfigured with a cartridge fluidic structure with respect to the respective unit operation, are being stored in a cartridge storage unit of the unit operation station and that for performing the respective unit operation, one of the cartridges is being transported from a storage transfer location in a cartridge storage unit of the unit operation station to a drive location of a cartridge drive unit of the unit operation station by a local transport mechanism of the unit operation station and is being brought into operative coupling with the cartridge drive unit.