11 results about "Dose drugs" patented technology

Provided is use of a compound represented by Formula (I), or a stereoisomer, tautomer, solvate or pharmaceutically acceptable salt of the compound represented by Formula (I) in the manufacture of a medicament for treating and / or preventing an immune system disease.

The invention concerns improvements in needle-free devices for delivery of therapeutic and / or prophylactic agents, such as solid dose drugs, including vaccines. The needle-free device disclosed herein comprises novel structural arrangements and modes of actuation and operation, resulting in enhanced functionality and benefits to the user and / or patient.

The invention concerns improvements in needle-free devices for the delivery of therapeutic and / or prophylactic agents, such as solid dose drugs, including vaccines. The needle-free devices disclosed herein comprises novel structural arrangements and modes of actuation and operation, resulting in enhanced functionality and benefits to the user and / or patient.

This invention provides an atomization module for an atomizer, comprising a pressure-resistant solution chamber, a pressure assembly, a heating assembly, and a sealing nozzle. The pressure assembly is connected to the pressure-resistant solution chamber and can increase the pressure inside the chamber. The sealing nozzle is connected to an outlet on the pressure-resistant solution chamber and includes a transition section and a spray plate. The spray plate has an internally closed blind hole. The transition section, the blind hole, and the outlet are interconnected. The blind hole opens from the inside out after exceeding the pressure limit, and the liquid to be atomized is sprayed out from the blind hole. The inner diameters of the pressure-resistant solution chamber, the transition section, and the blind hole decrease sequentially. The heating assembly can heat the pressure-resistant solution chamber. The atomization module of this invention has a faster atomization rate, a larger capacity range for atomized solution per spray, and no special requirements on the device posture during atomization. It can deliver both micro-dose and large-dose drugs as needed, making it more widely applicable.

The invention discloses a sitagliptin phosphate pharmaceutical composition as well as a preparation, a preparation method and application thereof. The pharmaceutical composition comprises sitagliptin phosphate, HP-beta-CD and mesoporous silica. According to the invention, a synergistic effect is generated by utilizing a molecular-level clathration effect of HP-beta-CD and a nano-level confinement adsorption effect of mesoporous silica, so that chemical degradation of sitagliptin phosphate, especially generation of a genotoxic impurity NTTP, is remarkably inhibited from molecular and physical double levels, and the stability of a product is greatly improved. Meanwhile, the mesoporous silica effectively solves the technical problems that HP-beta-CD is strong in hygroscopicity and not easy to directly tablet, and the content uniformity of low-dose drugs is fundamentally ensured by forming uniform composite particles. The process is simple, granulation is not needed, the tablet is suitable for industrial production, the prepared tablet is excellent in stability and high in safety, and animal experiments show that the bioavailability of the tablet is superior to that of a commercially available reference preparation.

The invention discloses preparation of a mesoporous drug-loading system with a controllable aperture and application of the mesoporous drug-loading system in improvement of oral absorption of insoluble drugs, and belongs to the technical field of medicines. The drug loading system takes dendritic mesoporous silica as a carrier of an insoluble drug and fenofibrate as a model drug, is used for improving the physical stability and oral bioavailability of the insoluble drug, and is particularly suitable for clinical large-dose drugs. The dendritic mesoporous silica drug-loading system provided by the invention is superior to commercially available mesoporous auxiliary materials and traditional solid dispersion carrier materials in the aspects of improving the physical stability of the insoluble drug and enhancing the oral absorption effect, and provides important reference for the research of an oral preparation of the insoluble drug.

The invention concerns improvements in needle-free devices for delivery of therapeutic and / or prophylactic agents, such as solid dose drugs, including vaccines. The needle-free device disclosed herein comprises novel structural arrangements and modes of actuation and operation, resulting in enhanced functionality and benefits to the user and / or patient.

The embodiment of the invention provides an injector for injecting medicine with adjustable dosage, and belongs to the technical field of medical instruments. The trigger mechanism comprises a button and a knob which are clamped together; the adjusting mechanism comprises gear sets meshed together, one end of the adjusting mechanism is fixed to the injector shell and rotatably connected with the triggering mechanism, the other end of the adjusting mechanism is fixedly connected with the adjusting rod, and a torsional spring is arranged in the adjusting mechanism; the push mechanism comprises a push rod and a push part; one end of the push rod is fixedly connected with the button; the other end of the push rod is meshed with the gear set; one end of the push part is fixedly connected with the adjusting rod; the knob is rotated to drive the adjusting rod to rotate to a preset dosage position, and meanwhile the gear set rotates in an engaged mode to enable the torsional spring to store force. The button is pressed to drive the push rod to axially move towards the injection end, so that the gear set is separated, and the torsion spring force release adjusting rod rotates to push the pushing part to push quantitative medicine to complete injection. The injector can adjust and lock the dosage and then automatically inject.

This utility model discloses a water treatment dosing device, including a base, an aeration pump on one side of the inner wall of the base, and an air supply pipe connected to the air outlet of the aeration pump. A drive motor is located on one side of the inner wall of the base, and a dosing tank is located at the center of the top of the base. An air injection pipe is located at the bottom of the inner wall of the dosing tank. One end of the air supply pipe is mounted on the top of the air injection pipe via a bearing, and the bottom end of the air injection pipe is fixedly connected to the output end of the drive motor via a flat key. Multiple stirring rods are welded to the outside of the air injection pipe, and multiple air holes are opened on the outside of the air injection pipe. When mixing aqueous solution and chemicals, the aeration pump is started, and the aeration pump injects air into the air injection pipe through the air supply pipe. The air is discharged through the air holes on the air injection pipe. The forced airflow will disturb the chemical particles, achieving full dispersion of the chemical particles. For active ingredients with poor solubility or easy separation, it can significantly improve the uniformity of low-dose drugs and reduce the risk of clumping of hygroscopic drugs due to uneven humidity.