30 results about "Fractional flow reserve" patented technology

Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties / analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties / analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data.

The invention provides a system and method for using computational fluid mechanics to simulate and calculate fractional blood flow reserve. The system comprises a vascular tree model generation module, a computational grid generation module, a boundary condition setting module, an attribute setting module, a solver and an aftertreatment module, wherein the vascular tree model generation module acquires a medical image, executes segmentation and reestablishes a geometric model of a vascular tree of an individual, the computational grid generation module generates a computational grid for the geometric model and establishes a CFD model of the vascular tree, the boundary condition setting module sets corresponding inlet and outlet boundary conditions for the CFD model of the vascular tree, the attribute setting module sets the physical property and a flow equation of blood, the solver seeks solutions on the CFD model of the vascular tree based on the inlet and outlet boundary conditions so as to obtain fluid parameters around the vascular tree, the set physical property and the flow equation, and the aftertreatment module conducts aftertreatment on the fluid parameters so as to obtain the fractional blood flow reserve, and both the inlet boundary condition and outlet boundary condition have individual specificity. According to the system and method for using computational fluid mechanics to simulate and calculate the fractional blood flow reserve, the accuracy of a simulation result is guaranteed, and the calculation time acceptable to clinics can be achieved at the same time.

The invention relates to a processing apparatus for processing cardiac data of a living being and to an imaging system comprising the processing apparatus. A distribution of Fractional flow reserve (FFR) values being indicative of the FFR of different coronary arteries of the living being, a distribution of myocardial perfusion values like values of an iodine map being indicative of the myocardial perfusion of different portions of the myocardium of the living being and assignments between coronary arteries and portions of the myocardium of the living being are used for determining degrees of correspondence between FFR values and myocardial perfusion values. This allows for, for example, a determination of the reliability of the FFR values, if the myocardial perfusion values are known to be reliable, based on the determined degrees of correspondence.

A processing system received data from a Fractional Flow Reserve device and communicates data to a conventional hemodynamic monitoring system having pressure displays. The processing system receives proximal pressure measurement signal from an aortic pressure measurement device and a distal pressure measurement signal from a distal pressure measurement device. A processor computes an FFR ratio from the proximal pressure measurement signal and the distal pressure measurement signal, and converts FFR ratio to a pressure format such that the FFR ratio reads on the conventional hemodynamic monitoring system as a pressure in units of pressure. The processing system transmits the proximal pressure measurement signal, the distal pressure measurement signal, and the FFR ratio in pressure format to the conventional hemodynamic monitoring system.

The embodiment of the invention discloses a system and method and equipment for evaluating frictional blood flow reserve and a storage medium. The system comprises an obtaining module, a narrow rate determining module, a model determining module and an FFR calculating module. The obtaining module is used for obtaining three-dimensional image information of the coronary artery, determines distribution information of dragon bone joints of the coronary artery according to the three-dimensional image information of the coronary artery, and obtains information parameters of the dragon bone joints;the narrow rate determining module is used for determining the narrow rate of the coronary artery according to the information parameters of the dragon bone joints of the coronary artery; the model determining module is used for determining an FFR evaluating model according to the relation of the narrow rate of the coronary artery and a preset narrow rate; the FFR calculating module is used for calculating the FFR value of the coronary artery according to the information parameters of the dragon bone joints and the FFR evaluating model.

The invention discloses a hemodynamic force simulation method and device. The method comprises the following steps: acquiring a blood vessel image of an artery blood vessel in a predetermined area of a target object; performing level set segmentation on an initial blood vessel model corresponding to the blood vessel image to obtain a segmented blood vessel model; acquiring a boundary condition for simulating a target blood vessel corresponding to the blood vessel model; performing central arterial pressure calculation on the target blood vessel to obtain an inlet pressure value of the target blood vessel; and performing hemodynamic simulation on the target blood vessel by using the boundary condition and the inlet pressure value. The technical problem that in the related technology, potential safety hazards exist in invasive fractional flow reserve measurement, and consequently the reliability of hemodynamic simulation is low is solved.

The invention provides a system for simulating computational fractional flow reserve by applying computational fluid mechanics and a method thereof. The system comprises a vascular tree model generation module which acquires a medical image, performs segmentation and reconstructs the geometric model of an individual vascular tree; a computational grid generation module which generates a computational grid for the geometric model and establishes the CFD model of the vascular tree; a boundary condition setting module which sets the corresponding entry and exit boundary conditions for the CFD model of the vascular tree; an attribute setting module which sets the physical attributes and the flow equation of the blood; a solver which solves the CFD model of the vascular tree based on the entryand exit boundary conditions and the set physical attributes and the flow equation so as to obtain the fluid parameters of each position of the vascular tree; and a post-processing module which post-processes the fluid parameters so as to obtain the fractional flow reserve, wherein the entry and exit boundary conditions are individual-specific. According to the system and the method, the accuracyof the simulation result can be ensured and the clinically acceptable computational time can be realized.

A medical system includes a medical instrument (102) configured for interventional deployment and a shape sensing system (104) mounted on or in the medical instrument and configured to measure a shape of the medical instrument during the interventional deployment. An imaging device (106) is mounted on or in the medical instrument and configured to image a lumen in which the imaging device is deployed. A registration module (140) is configured to register the shape of the medical instrument to an image of the lumen at a particular time to reconstruct a three-dimensional geometry of the lumen, accounting for motion.

Catheters, such as fractional flow reserve catheters, include an elongated shaft with a pressure sensing wire extending to a distal portion of the elongated shaft. The wire has a pressure sensor mounted on the distal end for measuring the pressure of the fluid within the lumen of the vessel. The pressure sensor wire is disposed within a dimple formed adjacent to the pressure sensor, thereby minimizing the catheter profile. The bending stresses experienced by a pressure sensor mounted to a fractional flow reserve catheter as the catheter is advanced through the vasculature produce deformation of the sensor, resulting in incorrect pressure readings or bending errors. To isolate the sensor from bending stresses, the sensor is spaced apart from the pressure sensor wire to allow the pressure sensor and pressure sensor wire to move independently of each other.

The embodiment of the present invention discloses a method, device, device, and storage medium for evaluating blood flow reserve fraction. The method includes: determining the keel node distribution of the coronary artery to be detected; analyzing the keel node distribution to obtain the coronary artery to be detected The branch path of the artery; taking the keel node of the coronary artery as a node, dividing the coronary artery into a plurality of flow elements, wherein the length of the flow element is the distance between adjacent nodes; according to the coronary artery According to the flow rate of the branch path of the pipe flow element, the pressure loss parameter of the pipe flow element is obtained; according to the pressure loss parameter of the pipe flow element and the preset equivalent calculation strategy, the pressure loss of the pipe flow element and the pressure loss of the keel node are obtained Pressure distribution: According to the pressure distribution of the keel node, the blood flow reserve fraction of the coronary artery is obtained.

The invention discloses a method and device for measuring blood flow reserve fraction, wherein the method includes: obtaining the vascular characteristic parameters of the target patient's coronary artery, wherein the vascular characteristic parameters include the vascular cross-sectional radius at the set position, and the coronary artery Stenosis characteristic parameters of arterial vessel stenosis areas; inputting said blood vessel characteristic parameters into a pre-established fractional blood flow reserve measurement model to obtain fractional blood flow reserve of said target patient. The invention solves the problems of time-consuming measurement of blood flow reserve fraction and high requirement for equipment calculation, and can measure blood flow reserve fraction efficiently, accurately and in real time.

The invention discloses a computer-aided surgery design system for coronary heart disease, which includes a clinical inspection module, a computer-aided module and a diagnosis and treatment module which are connected in sequence; Have coronary heart disease or related heart disease; computer-aided modules, including segmentation and reconstruction of coronary vessels module 3 and calculation of vascular stenosis module 4, segment and reconstruct angiographic images, apply computational fluid dynamics technology, and calculate coronary blood flow reserve fraction quantitative judgment Whether it is necessary to perform coronary interventional surgery; the diagnosis and treatment module is composed of a doctor review module 5 and an auxiliary surgery module 6. The doctor review module 5 feeds back the calculation results to make the calculation results more credible. The present invention relates to coronary heart disease The advanced computer-aided surgical design system can intuitively display the anatomical structure of coronary artery, making the diagnosis of coronary heart disease more intuitive and scientific.

Embodiments of the present invention disclose a system, method, device, and computer-readable storage medium for evaluating fractional blood flow reserve, wherein the system includes: an acquisition module configured to acquire three-dimensional image information of coronary arteries, according to the coronary arteries The three-dimensional image information of the artery determines the distribution information of the keel nodes of the coronary arteries, and obtains the information parameters of the keel nodes; the stenosis rate determination module is used to determine the stenosis rate of the coronary arteries according to the information parameters of the keel nodes of the coronary arteries The model determination module is used to determine the model for evaluating the FFR according to the relationship between the stenosis rate of the coronary artery and the preset stenosis rate; the FFR calculation module is used to calculate the FFR value of the coronary artery based on the keel node information parameters and the evaluation FFR model.

The present invention relates to blood flow reserve fraction, and in particular to a method for obtaining vascular blood flow reserve fraction. The non-linear diffusion filter of the differential equation denoises the sequence image data; C. Segments the blood vessel image from the background image; D. Performs wavelet edge detection on the blood vessel image, and extracts the edge of the blood vessel image by decomposing the mutation point of the image E. Obtain the vascular blood flow reserve fraction according to the time interval between the vascular image and each frame of image; A method for obtaining fractional blood flow reserve, and a corresponding device.

The present invention proposes a method for establishing a blood flow calculation model to evaluate coronary blood flow, including: establishing a three-dimensional model of the heart, including: obtaining a two-dimensional grayscale picture of the CT imaging of the heart by scanning with a CT device, and converting the heart The two-dimensional grayscale images of CT imaging are binarized and stacked according to the preset relationship to obtain the three-dimensional structure of the coronary artery after stacking; the fluid dynamics model of the blood is established, including: using adaptive local encryption technology to analyze the structure of the three-dimensional heart model Carry out discrete gridding to generate an adaptive dense grid; establish a lattice Boltzmann method LBM blood flow calculation model based on the adaptive dense grid; calculate the fractional blood flow reserve (FFR). The fluid calculation model established by the present invention has the characteristics of high calculation accuracy and high efficiency, so that the calculated blood flow reserve fraction has high accuracy and less calculation time, and the evaluation of coronary artery blood flow has higher accuracy and higher efficiency.

The application discloses a blood flow reserve fraction calculation method, device, electronic equipment and readable storage medium. The method provided by this application determines the pressure drop prediction value through the arterial characteristic parameters after dimension reduction, so compared with the calculation method of three-dimensional fluid dynamics, the calculation speed is faster, and the pressure drop correction value prediction processing is performed on the pressure drop prediction value to obtain The correction value of the pressure drop corrects the predicted value of the pressure drop, which overcomes the inaccurate shortcomings of the predicted value of the pressure drop. Therefore, the whole process of calculating the blood flow reserve fraction not only ensures that the calculation speed is better than the traditional method, but also ensures the blood flow obtained in the final calculation. Reserve scores are highly accurate.

A medical system includes a medical instrument (102) configured for interventional deployment and a shape sensing system (104) mounted on or in the medical instrument and configured to measure a shape of the medical instrument during the interventional deployment. An imaging device (106) is mounted on or in the medical instrument and configured to image a lumen in which the imaging device is deployed. A registration module (140) is configured to register the shape of the medical instrument to an image of the lumen at a particular time to reconstruct a three-dimensional geometry of the lumen, accounting for motion.

The present disclosure facilitates the evaluation of broadband phase gradient information of cardiac tissue to assess, for example, the presence of cardiac ischemic heart disease. Notably, the present disclosure provides an improved and efficient method for identifying and risk stratifying coronary artery stenosis of the heart using high resolution and broadband cardiac gradients acquired from patients. In some embodiments, patient data is derived from cardiac gradient waveforms of one or more leads, resulting in high-dimensional data and long cardiac gradient records exhibiting complex nonlinear changes. Through numerical wavelet operators, spatiotemporal analysis is used to study the morphology of cardiac gradient data as a phase space dataset by extracting dynamic and geometric properties from the phase space dataset.

A non-invasive calculation method for FFR of superior mesenteric artery dissection based on CT images, comprising the following steps: S01: image acquisition; S02: extraction of superior mesenteric artery ostium; S03: extraction of superior mesenteric artery; S04: generation of superior mesenteric artery grid model; S06: Superior mesenteric artery FFR CT Calculation: by formula FFR CT =P d / P a Calculate the fractional flow reserve, where P a is the blood pressure upstream of the mesenteric dissection, P d is the blood pressure downstream of the mesenteric dissection; S07: Carry out the above experimental steps on the patient's CTA image, and calculate the FFR CT value. Based on the CT image of the mesenteric artery, the present invention can quickly and accurately obtain the fractional blood flow reserve (FFR) automatically.

The embodiment of the present invention discloses a system, method, terminal and storage medium for determining FFR. The system includes: an acquisition module for acquiring the relationship between blood detection information and blood flow model parameters; an image processing module for acquiring image data of an individual heart , to separate the three-dimensional image data of myocardium and coronary arteries; the impedance calculation module is used to calculate the coronary artery outlet impedance; the viscosity coefficient calculation module is used to obtain individual blood test information, according to the hematocrit and blood The relationship between the detection information and the parameters of the blood flow model is used to calculate the viscosity coefficient; the blood flow parameter calculation module is used to divide the grid data according to the boundary conditions, the blood density and viscosity coefficient in the blood detection information, and the three-dimensional image data of the coronary artery, The blood flow parameter information of the coronary artery is obtained; the FFR determination module is configured to determine the coronary FFR according to the relationship between the second set pressure and the blood flow parameter information.

The present application relates to a method, device, system and computer storage medium for calculating fractional blood flow reserve based on intracavitary images, wherein the method for obtaining fractional blood flow reserve includes step S1 of acquiring image data related to coronary vessels, by The processing of the image data constructs a corresponding three-dimensional blood vessel model; wherein the image data related to coronary vessels includes: intracavitary image data and coronary angiography image data; Step S2, calculate blood flow according to the three-dimensional blood vessel model and a fluid dynamic method Equation to obtain the hemodynamic parameter distribution of the coronary arteries in the region represented by the three-dimensional vascular model; step S3, calculating the blood flow reserve fraction according to the hemodynamic parameters obtained in step S2. The invention can accurately calculate and obtain the patient's coronary artery FFR.

The invention discloses a method for calculating the blood flow reserve fraction based on a pressure sensor and contrast images, comprising: collecting the pressure of the heart coronary artery in real time through a blood pressure sensor, storing the pressure value in a data linked list, and the data linked list takes time as an index, and uses The time and real-time pressure values ​​are saved in the form of key-value pairs; the contrast time is obtained according to the contrast image, and the contrast time is used as the index value to find the corresponding data from the data queue according to the time index, and the stable pressure waveform of multiple cycles is screened out to obtain the average pressure Pa; obtain the length of a section of blood vessel from the contrast images of two body positions, and obtain the blood flow velocity V; calculate the pressure drop ΔP at the entrance blood flow velocity V in this section of blood vessel, calculate the distal pressure Pd of the vessel, and further calculate the contrast blood flow reserve score. The stable pressure value after creating the contrast agent can be accurately obtained, and the average blood flow velocity of a cardiac cycle can be accurately obtained through the pressure waveform and contrast images, which can greatly improve the accuracy of FFR.