6 results about "Lanthionine" patented technology

The application discloses a carbonyl heterocyclic compound and application thereof. The application provides a carbonyl heterocyclic compound as shown in formula II or a pharmaceutically acceptable salt thereof; the compound can be used as a compound with a targeted lipoamide synthetase C-like protein 2 path; and the compound can be used for treating various conditions, including infectious diseases, autoimmune diseases, diabetes and chronic inflammatory diseases.

Provided are compounds that target the lanthionine synthetase C-like protein 2 pathway. The compounds can be used to treat a number of conditions, including infectious disease, autoimmune disease, diabetes, and a chronic inflammatory disease.

The invention belongs to the technical field of pet nutritional and functional food processing, and particularly relates to a pet dog epidermis-hair follicle synergistic repair daily ration and a preparation method thereof. The daily ration comprises phytosphingosine, N-stearoyl-L-serine, cholesterol, L-lantidine and epsilon-(gamma-glutamyl)-lysine according to a specific proportion, and the phytosphingosine, the N-stearoyl-L-serine and the cholesterol, the L-lantidine and the epsilon-(gamma-glutamyl)-lysine are respectively used as a cuticle lipid reconstruction precursor and a hair keratin directional cross-linking enhancer. The preparation method comprises the following steps: microencapsulating a lipid precursor, mixing the microencapsulated lipid precursor with a cross-linking agent solution and a basic ration, and instantaneously injecting steam at 105-110 DEG C at 48-52 DEG C by adopting a low-temperature pulse granulation process for forming. According to the method, the activity of thermosensitive components can be protected to the maximum extent, the two functional components can synergistically play the roles of repairing skin barriers and strengthening hair structures in vivo, the water content of the skin of the pet dogs is remarkably increased, water loss is reduced, and the breaking strength and luster of hair are enhanced.

Provided are compounds that target the lanthionine synthetase C-like protein 2 pathway. The compounds can be used to treat a number of conditions, including infectious disease, autoimmune disease, diabetes, and a chronic inflammatory disease.

A peptide capable of binding to Lanthionine synthetase C-like (LanCL) protein, wherein the peptide comprises an amino acid sequence of formula (I):X1-X2-X3-X4-X5-X6  (I)wherein:(a) X1 is selected from the group consisting of lysine, arginine and histidine, or X1 is absent;(b) X2 is selected from the group consisting of alanine, valine, leucine, isoleucine, proline, phenylalanine, cysteine, tyrosine and serine;(c) X3 is selected from the group consisting of glycine, alanine, valine, leucine and isoleucine;(d) X4 is selected from the group consisting of serine, cysteine, threonine, asparagine, arginine, glutamine, tyrosine, aspartic acid, lysine, glutamic acid, proline and histidine, or X4 is absent;(e) X5 is selected from the group consisting of serine, cysteine, threonine, asparagine, arginine, glutamine, tyrosine, lysine, histidine and glycine, or X5 is absent; and(f) X6 is selected from the group consisting of serine, cysteine, threonine, asparagine, glutamine, tyrosine, and histidine, or X6 is absent,wherein the peptide is from 3 to 20 amino acids in length;wherein the amino acid sequence of the peptide does not comprise CRSRPVESSC (SEQ ID NO:13), CRSVEGSCG (SEQ ID NO:7), or CRIIHNNNC (SEQ ID NO:24); andwherein the peptide is not a linear peptide comprising the amino acid sequence EQLERALNSS (SEQ ID NO:65).

The purpose of the present invention is to provide a novel TRPA1 agonist. The present invention relates to a composition for activating TRPA1, comprising a mushroom extract or lanthionine. The composition can enhance appetite and food consumption and ameliorate decreased appetite.