The application discloses a method for establishing a Bama
miniature pig spleen deficiency and dampness excess model, and belongs to the technical field of animal models. The method is to reduce the
immunity of the body by
intraperitoneal injection of
cyclophosphamide, and then to stimulate the Bama
miniature pig by using high-
sugar and high-fat feed and
senna leaves in combination with a high-
humidity external environment. After 8 weeks, the Bama
miniature pig has the clinical manifestations of the
spleen deficiency and dampness excess, such as body fatness, fatigue and laziness, white and slippery
tongue fur, and loose and watery stool, and the model is verified in the reverse direction by using the classic compound Shenglin Bai Zhusan. The Bama miniature pig
spleen deficiency and dampness excess model is applied to the research of human spleen deficiency and dampness excess and the development of spleen-invigorating and dampness-expelling drugs. The model provides a new model for standardizing, standardizing and scientifically evaluating the research of spleen-invigorating and dampness-expelling traditional Chinese medicines, and has the advantages of good practicability, strong conformity, simplicity and objectivity, and conforms to the guidance of the theory of
traditional Chinese medicine syndromes, and has a wide application prospect.