The invention discloses a vehicle-mounted device integrating eyeball tracking and gesture control. The vehicle-mounted device comprises a head-up display and a 3D depth sensing module, wherein the 3Ddepth sensing module is arranged on an automobile central control platform, is connected with the head-up display, can emit infrared diffracted speckles, project to the eyeball position of a driver and receive the infrared speckles reflected by the eyeballs; a reflection vector formed by the non-repetitive speckle falling in the eyeball and the pupil is utilized to define the eyeball position, thesight line drop point is tracked and corrected according to the change of the reflection vector caused by pupil movement at the position; compensation calculation is carried out through a sight linemapping function, the sight line drop point position is calculated, when the sight line drop point position is located on the front windshield of the automobile, feedback display of the head-up display is controlled, and when the sight line drop point position is located on a control interface, gesture recognition calculation is started, and gesture control over the system in the automobile is carried out.