The invention relates to a settling, isolating and removing integrated dust prevention method of a fully mechanized excavation face, and is applicable to dust prevention and control of a coal mine underground fully mechanized excavation face. The method comprises the steps that: a foam generator is installed on a fully-mechanized roadheader, a pneumatic dedusting fan is arranged at one side of a laneway, and a wall attaching wind drum is installed at the front end of a pressed-in type wind drum; when the fully-mechanized roadheader works, the foam generator is operated to prepare foam, and the foam is sprayed by a spraying head to a dust source at the cutting part of the fully-mechanized roadheader so as to rapidly settle the dust; the axial air flow in the pressed-in type wind drum is changed by the wall attaching wind drum into a spiral type air flow and then sprayed, so as to prevent the air flow from directly blowing to the foam spraying region to influence the foam track; an air curtain dust isolating region is formed in front of the driver of the fully-mechanized roadheader, so as to effectively prevent dust from diffusing out; and the residual dust in the dust isolating region is removed by starting the pneumatic dedusting fan. According to the invention, foam dust settling, air curtain dust isolating and pneumatic fan dedusting are organically integrated, thus the dust prevention effect of the fully mechanized excavation face is significantly improved, the potential safety hazard brought by using of an electric dedusting fan is avoided, and the method has wide practicability.