The invention discloses a microwave high-temperature heating heat-generating material containing MoSi2 and a preparation method thereof in the technical field of microwave high-temperature heating heat-generating materials. The microwave high-temperature heating heat-generating material containing MoSi2 is prepared by compounding MoSi2 and a microwave strongly absorbing material on the basis of the excellent high-temperature inoxidability and excellent microwave absorbing property of the MoSi2. The using forms of the MoSi2 comprise powder, slurry and plate. The microwave strongly absorbing material compounded with the MoSi2 is one or a mixture of more than one of SiC, AlN, C, CuO and Fe3O4. The microwave high-temperature heating heat-generating material of the invention is used as a heat-generating material to replace a resistance wire, a silicon carbide rod, a silicon-molybdenum bar and other traditional heating elements, has the advantages of excellent high-temperature inoxidability, long service life, quick temperature rise, large heat-generating area, uniform heating and energy conservation, is particularly suitable to be used as a microwave high-temperature heating unit to replace a heating element in the conventional electric furnace and can also be used as a novel microwave absorbing material.