The invention relates to a safety interaction system, which comprises a man-machine interaction system and a man-machine interaction device, the man-machine interaction system comprises a safety application and a safety service, and the safety application generates or receives corresponding secret spelling and/or secret sound spelling between one-time plaintext and ciphertext generated by the safety service. The method comprises the following steps: displaying and/or playing to a user or an administrator, and enabling the user or the administrator to carry out autonomous, unlimited and unlimited man-machine security interaction in a contact or non-contact manner through a standard keyboard, mouse, voice or gesture manner under the condition that the existing man-machine interaction equipment and application software and a security mechanism thereof are not changed at all; and the security of the interacted plaintext information is protected. The invention further discloses a secure interaction method, electronic equipment and a storage medium. According to the invention, through one-time man-machine security interaction, no plaintext appears in the whole process, and the leakage risk that sensitive information is secretly shot, eavesdropped, screenshot, secretly recorded, intercepted and the like in the man-machine interaction process is effectively avoided.