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The invention belongs to the technical field of medical equipment, and discloses an optical dustproof structure and ophthalmic medical equipment. The optical dustproof structure comprises a fixed lens assembly, a focusing assembly and a sealing middleware, the fixed lens assembly comprises a fixed lens cone and a fixed lens group arranged in the fixed lens cone, the focusing assembly comprises a focusing lens cone and a focusing lens group arranged in the focusing lens cone, and the focusing assembly can move relative to the fixed lens assembly. In the process that the focusing assembly moves relative to the fixed lens assembly, the sealing middleware enables the fixed lens set and the focusing lens set to be sealed and isolated, and the sealing middleware can be driven by all or part of movement of the focusing assembly to move and is not completely static relative to the focusing assembly. The ophthalmic medical equipment comprises the optical dustproof structure. The optical path between the fixed lens group and the focusing lens group can be effectively protected, external impurities are prevented from being grazed in, dust is prevented from entering, and the impurities and the dust are prevented from being deposited on the lenses of the fixed lens group and the focusing lens group to affect imaging.