31results about How to "Simplified and efficient" patented technology

A process is provided for the semi-synthesis of taxane derivatives useful in the preparation of docetaxel, in particular, the semi-synthesis of protected taxane derivatives in a one pot reaction of protecting the C-2′, C-7 and C-10 and introducing a t-Boc group at the nitrogen of the amide group at the C-3′ position in paclitaxel and subsequently conversion to docetaxel, and derivatives used therein.

In the present invention, a sequence segment conforming to the following rules (a) to (d) is searched from the base sequences of a target gene of RNA interference and, based on the search results, siRNA capable of causing RNAi is designed, synthesized, etc.: (a) The 3′ end base is adenine, thymine, or uracil, (b) The 5′ end base is guanine or cytosine, (c) A 7-base sequence from the 3′ end is rich in one or more types of bases selected from the group consisting of adenine, thymine, and uracil, and (d) The number of bases is within a range that allows RNA interference to occur without causing cytotoxicity.

The present invention relates to a DC/DC converter (1) with primary side (11) consisting of a resonant converter, which DC/DC converter (1) comprises a first and a second transformer (T1, T2), connected in series on the primary side (11) and on the secondary side (12) of the DC/DC converter. The secondary side (12) comprises an autotransformer (Tcd) consisting of a first and a second winding (Tcda, Tcdb) connected to a common center tap (Tcdc), where the first winding (Tcda) of the autotransformer (Tcd) is connected to the secondary winding (T1b) of the first transformer (T1), forming a first output connection point (P1), the second winding (Tcdb) of the autotransformer (Tcd) is connected to the secondary winding (T2b) of the second transformer (T2), forming a second output connection point (P2), and the center tap (Tcdc) of the autotransformer (Tcd) is connected to the positive output (21) of the secondary side (12). The secondary side (12) also comprises a first and a second rectifying switching device (S1, S2), where the first rectifying switching device (S1) is connected between the first output connection point (P1) and the negative output (22) of the secondary side (12), and the second rectifying switching device (S2) is connected between the second output connection point (P2) and the negative output (22) of the secondary side (12). The present invention also relates to a DC/DC converter system comprising at least two inventive DC/DC converters (1).

A method for preparing the tinted contact lens with the covalently bonded novel reactive tinting compound is disclosed. The reactive tinting compound with mono vinyl functionality is prepared by reacting the reactive dye with a hydrophilic monomer containing both pendent hydroxyl and vinyl groups under an alkaline condition. The water soluble reactive dyes containing either difluoro-chloropyrimidine or β-sulphatoethylsulphone reactive groups are used for synthesis of the reactive tinting dye. The lens forming materials is photo-polymerized in the presence of the reactive tinting compound to prepare a tinted contact lens. The reactive tinting compound is copolymerized with the lens forming monomers in a single photo-polymerization step that required no subsequently alkaline soaking or developing step as used in the prior art. In addition, the covalently bonded dye is stable and durable in the lens and does not fade or leach out after multiple high-pressure thermal sterilization.

The use of power-efficient transmitters to establish acoustic wave energy having low undesirable harmonics is achieved by adjusting the transmitter output waveform to minimize the undesirable harmonics. In one embodiment, both the timing and slope of the waveform edges are adjusted to produce the desired output waveform having little or no second harmonics. In the embodiment, output waveform timing adjustments on the order of fractions of the system clock interval are provided. This then allows for very fine control of a coarsely produced waveform. In one embodiment, the user can select the fine tuning to match the transmitter output signal to a particular load transducer.

A method for preparing the tinted contact lens with the covalently bonded novel reactive tinting compound is disclosed. The reactive tinting compound with mono vinyl functionality is prepared by reacting the reactive dye with a hydrophilic monomer containing both pendent hydroxyl and vinyl groups under an alkaline condition. The water soluble reactive dyes containing either difluoro-chloropyrimidine or beta-sulphatoethylsulphone reactive groups are used for synthesis of the reactive tinting dye. The lens forming materials is photo-polymerized in the presence of the reactive tinting compound to prepare a tinted contact lens. The reactive tinting compound is copolymerized with the lens forming monomers in a single photo-polymerization step that required no subsequently alkaline soaking or developing step as used in the prior art. In addition, the covalently bonded dye is stable and durable in the lens and does not fade or leach out after multiple high-pressure thermal sterilization.

A compact multi-lumened hysteroscope, a single-use tissue resector, and a medical system employing the same for diagnosis and therapeutic treatment of uterine tissue, such as polyps and fibroids.

A utility cart for maneuvering trailers and trailer accessories includes a base frame member, caster wheels mounted on an underside of the base frame member, a height adjustable hitch assembly, and a pair of handles extending upwardly from the base frame member. The hitch assembly is mounted to the central support members, and includes a vertical post extending upwardly from the support members and a telescoping frame member with a vertical sleeve that mates telescopically with the vertical post. The telescoping frame member includes a height adjustment mechanism that is operated by a hand crank, so that a user can turn the hand crank to raise or lower the height of the telescoping frame member. The utility cart may attach to trailers, trailer hitch accessories, or may be used as a docking station for the recreational vehicle loading and carrying apparatus set forth in U.S. Pat. No. 9,670,013.

The invention relates to a fuse protector which solves the problem that manufacturing cost is increased since except for rivets and screws, all parts, such as wiring terminals, outer end caps and inner end caps, of an A-type fuse protector and a C-type fuse protector in traditional standards are involved in electric conduction and must be made of copper materials. The fuse protector comprises an insulation tube, a fuse link is arranged inside the insulation tube, two ends of the fuse link are connected with wiring terminals, wiring ends of the wiring terminals extend out of the insulation tube, positioning pads used for fixing the wiring terminals are respectively arranged on the corresponding wiring terminals in a sleeved manner and fit with tube openings of the insulation tube, and outer end caps compressing the positioning pads and sealing the tube openings of the insulation tube are arranged on the insulation tube. The fuse protector is totally different from current various domestic and foreign fuse protectors in construction and structure principles and has the advantages of ingenious and novel design concept, wide and practical promotional significance, simplicity and efficient economic benefit and universal value.

Provided is a heat dissipation structure and an illumination device which are capable of dissipating heat readily and efficiently. A heat dissipation structure 1 configured to release heat from a heat source 100 is provided with a plurality of heat reception/dissipation members 10 which have expanded graphite layers containing expanded graphite and which are spaced apart from each other; and a connection member 20 configured to connect the heat reception/dissipation members 10 together. The heat reception/dissipation members 10 each have the expanded graphite layer as the outermost layer and are disposed such that the expanded graphite layers face each other.

A packaging method for a tire pressure monitoring sensor includes a step of placing, a step of pouring, and a step of hardening. In the step of placing, a sensing transmission module is put into a cavity of a modeling unit, and a positioning portion in the cavity restricts the sensing transmission module from moving transversely and toward an inner bottom of the cavity. In the step of pouring, a rubber compound is poured into the cavity and fills the cavity. The sensing transmission module is coated by the rubber compound to form a case on the outer surface of the sensing transmission module. In the step of hardening, the case is hardened and integrally formed with the sensing transmission module to form a tire pressure monitoring sensor which is removed from the cavity.

A system and method for regionalized resolution of a network path to one or more file types based on a specific sound or a specific combination of words, phrases and/or sounds. An application with a user interface at a networked device has access to a remote speech to text server via an advanced programmer interface (API) and to a regionalized, accessible database. The regionalized, accessible database can contain text translations of distinct words, phrases, and sounds along with region(s) where the entries are valid that are associated with distinct network paths. Converted audio in a searchable format and location of the networked device are queried at the global database for a match, if a match is found at the regionalized database for the query, the network path associated with the match is returned from the regionalized database to the networked device, and one or more files associated with the returned network path are opened at the networked device.

A carrier and a component are disclosed. In an embodiment a component includes a semiconductor chip including a substrate and a semiconductor body arranged thereon and a metallic carrier having a coefficient of thermal expansion which is at least 1.5 times greater than a coefficient of thermal expansion of the substrate or of the semiconductor chip, wherein the semiconductor chip is attached to a mounting surface of the metallic carrier by a connection layer such that the connection layer is located between the semiconductor chip and a buffer layer and adjoins a rear side of the semiconductor chip, wherein the buffer layer has a yield stress which is at least 10 MPa and at most 300 MPa, and wherein the substrate of the semiconductor chip and the metallic carrier of the component have a higher yield stress than the buffer layer.

Disclosed is a method for producing a carbon composite material for a fuel cell separator, comprising dry homogenizing graphite powder as a conductive filler, a solid phenolic resin as a binder, and additives for improving physical properties, pouring the homogeneous mixture into a heated mold; and subjecting the homogeneous mixture to compression thermoforming. In accordance with the present invention, it is possible to prepare a carbon composite material for a fuel cell separator in a more simplified and efficient manner while requiring no preparation of intermediate materials such as granular particles and no graphitization treatment as used in conventional methods.