The invention discloses a safety intelligent lock system and an unlocking and locking control method. The safety intelligent lock system comprises a lock, a key, a portable electronic device and a remote main station, wherein the portable electronic device is in communication connection with the remote main station, the key is connected with the portable electronic device in a Bluetooth communication manner, the key is in communication connection with the lock, and the portable electronic device is provided with a Bluetooth module. Through the connection communication among the lock, the key, the portable electronic device and the remote main station, the unlocking action and locking action as well as a series of information verification before the unlocking are realized so as to guarantee safe unlocking. The key is small in size, the cost is low, intelligence, convenience in operation, safety and reliability can be achieved, and the unlocking by mistake can be prevented; meanwhile, by adopting the general control and information storage function of a communication network and the main station, the information of unlocking and locking such as an operation target, an operator, a target state, operation time and the like can be effectively recorded and managed, so that the management system in the electric power field can be completed.