6 results about "Phenylalanine derivatives" patented technology

A method for resolving a phenylalanine derivative of formula (I), and an intermediate. The method comprises: a resolving step comprising using a resolving reagent to react with the phenylalanine derivative represented by formula (I) in a reaction solvent to obtain a resolved intermediate, wherein the resolving reagent is selected from N-acetyl-D-phenylalanine and / or (2R,3R)-(−)-dibenzoyl-L-tartaric acid, and the reaction solvent is selected from 90-99% aqueous ethanol, absolute ethyl alcohol, or acetone. The method uses a chiral reagent to perform salt formation and racemate resolution, and has the advantages of being easy to operate, requiring no special production devices, and being easy to scale up production.

A novel crystalline complex of nicotinamide mononucleotide that is stable and highly safe is provided. The crystalline complex contains nicotinamide mononucleotide and a phenylalanine-based compound. The crystalline complex has L-phenylalanine or aspartame as the phenylalanine-based compound. The crystalline complex having L-phenylalanine as the phenylalanine-based compound has peaks at diffraction angles (2θ) of 19.7±0.2°, 26.4±0.2°, and 32.8±0.2° in a diffraction pattern of powder X-ray diffraction measured with a Cu-Kα ray as an X-ray source. The crystalline complex having aspartame as the phenylalanine-based compound has peaks at diffraction angles (2θ) of 7.0±0.2°, 10.7±0.2°, 14.4±0.2°, and 29.1±0.2° in a diffraction pattern of powder X-ray diffraction measured with a Cu-Kα ray as an X-ray source.

The present application relates to a kind of containing effective amount of novel acyl phenylalanine derivative of general formula (I), its preparation method and the use of the derivative as a pharmaceutical composition as a drug, compared with prior art, with more broad application prospect.

The application discloses a phenylalanine derivative small molecule self-assembly body with piezoelectric performance, a preparation method and application thereof, relates to the technical field of functional materials, and through introduction of a chiral solvent complementary to the configuration of the phenylalanine derivative small molecule and combination of reverse-solvent water synergistic regulation, the solution polarity is significantly changed, the small molecule solubility is reduced, the molecule is promoted to quickly and directionally nucleate and self-assemble, a highly ordered microstructure is formed, molecular-level chiral space control is realized, and the piezoelectric performance is improved. The piezoelectric material can be widely applied to the fields of flexible sensors, biomedical devices, energy collection devices and the like.

The invention discloses phenylalanine ammonia mutase and application of the phenylalanine ammonia mutase in preparation of R-type beta-amino acid. Compared with an amino acid sequence as shown in SEQ ID NO: 1, the amino acid sequence of the phenylalanine ammonia mutase comprises the amino acid residue difference of one or more of the following sites: the 59th site, the 60th site, the 144th site, the 233th site, the 247th site, the 281th site, the 304th site, the 330th site, the 394th site, the 396th site, the 399th site, the 403th site and the 427th site. The (R)-beta-phenylalanine derivative is synthesized by adopting the enzyme, so that the regioselectivity, enantiomer selectivity and conversion rate of the product can be obviously improved.

The disclosure relates to double halogenated phenylalanine derivatives, which can be radiolabeled with PET or SPECT radioisotopes, and their use in treating and / or imaging cancer.