The invention discloses a full-automatic medicine grinding device. The full-automatic medicine grinding device comprises a base, an L-shaped vertical plate is fixedly connected to one side of the upper surface of the base, an electric cylinder is fixedly mounted on the upper surface of the L-shaped vertical plate, a mounting plate is fixedly connected to the lower end of a telescopic rod of the electric cylinder, and a grinding motor is fixedly connected to the lower surface of the mounting plate. According to the full-automatic medicine grinding device, grinding work is automatically completed through the electric cylinder, the grinding motor, a conical grinding groove and a controller, manpower is greatly saved, the grinding efficiency is improved, a grinding pad and a sleeve pad are arranged, after grinding is completed, medicine is prevented from being adhered to a grinding instrument, cleaning is convenient, when medicine of different patients is ground, only the grinding pad and the sleeve pad need to be replaced, the problems that medicine residues exist and medicines of different patients are mixed are effectively avoided, a pressure sensor, an electric push rod and a tablet cutter are matched with the controller, the medicine needing to be cut can be rapidly and accurately cut, and manual cutting is not needed.