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Modular distributed cryogenic system
A modular distributed cryogenic distribution system, comprising: a common chamber housing cryogenic fluid conduits; and a plurality of cryochambers connected to the common chamber. A method of operating a modular distributed cryogenic distribution system comprising a common chamber housing cryogenic fluid conduits, and plural cryochambers connected to the common chamber, includes raising one the plurality of cryochambers room temperature while a second one of the plurality of cryochambers operates at a cryogenic temperature.
Owner:PSIQUANTUM CORP
Systems, apparatus and methods to pick and / or place specimen containers
ActiveUS12527318B2Lighting and heating apparatusStationary refrigeration devicesControl systemHydrology
A system, device and method to pick and / or place specimen containers may include a pick and / or place head, a first secondary reservoir, and optionally a second secondary reservoir which hold cryogenic fluid in a liquid form, above a main reservoir of cryogenic liquid, to cool the pick and / or place head and / or to cool or recharge the specimen containers during transfer operations. Storage locations may be arrayed in wedge-shaped sets spaced above cryogenic liquid of the main reservoir of a cryogenic storage tank at one or more levels, and pivotal about a central axis via a motor and control system. A gap (e.g., wedge shaped gap) between two successively angularly adjacent sets of storage locations of the sets of storage locations at an upper level provides access to the storage locations of the sets of storage locations at a lower level. Cryogenic liquid temperatures and levels in reservoirs are monitored.
Owner:TMRW LIFE SCIENCES INC
Defrost fan control
A refrigeration module of a cold space chamber has a blower and an evaporator. A method of controlling the refrigeration module includes defrosting a coil of the evaporator to form a volume of warm air surrounding the coil. The method includes circulating a refrigerant through the evaporator after defrosting the coil, to cool the coil. The method includes operating the blower in a series of pulses to control introduction of the volume of warm air into the cold space chamber.
Owner:TRANE TECHNOLOGIES LIFE SCIENCES LLC
Systems, devices, and methods for automated thawing of bag-format storage vessels
The present invention discloses sample thawing devices, systems, and methods, that are configured to take bag-format sample vessels, referred to as “cryobags”, and to thaw the contents of such cryobags. The contents of such cryobags are samples with cells, and the thawing of such samples is based on the temperature, volume, and mass of the sample in order to evenly distribute heat and avoid ice crystallization damage to the cells during thawing. Paired heater plates form an assembly configured to support, clamp, and thaw individual cryobags. The heater plate pair has an articulated member that is repositioning to provide for ease in inserting and removing samples.
Owner:BIOLIFE SOLUTIONS INC
Rapid-cooling, temperature-intensive cryogenic test chamber allowing for relative motion
PendingUS20250283792A1Preparing sample for investigationMaterial strength using tensile/compressive forcesTest chamberRelative motion
A cryogenic testing apparatus includes a housing in which a cryogenic chamber is positioned. An upper channel is arranged around the cryogenic chamber and is configured to receive a cryogen. A lower channel is arranged below the upper channel and is configured to receive cryogen from the upper channel. As the cryogen flows through the cryogenic testing apparatus, the cryogen contacts an exterior of the cryogenic chamber. The cryogenic chamber is unsealed and is configured to receive a gas to create positive pressure within the cryogenic chamber.
Owner:TEXAS A&M UNIVERSITY +1
Accommodation apparatus for freezing target
To increase the quantity of freezing targets stored in a storage space of a freezing container. A first accommodation unit 10 accommodating a first freezing target 91 includes a first female screw member 16a to which a part of a shaft member 80A is detachably coupled. A second accommodation unit 20 accommodating a second freezing target 92 includes a second female screw member 26a to which a part of the shaft member 80A is detachably coupled, and is arranged above the first accommodation unit 10 in a state of being stored in a freezing container 300. In a state where the second accommodation unit 20 is arranged above the first accommodation unit 10, the shaft member 80A is coupled to the first female screw member 16a to take out the first accommodation unit 10 and the second accommodation unit 20 collectively.
Owner:MEDIPAL HLDG CORP
Method for lyophilization and device thereof
PendingUS20260175219A1Preparing sample for investigationLaboratory glasswaresEngineeringBiochemistry
Owner:ARGONAUT MFG SERVICES INC
Automated storage module
ActiveCN114814260BLighting and heating apparatusPreparing sample for investigationBarcodeProcess engineering
This invention provides a cryogenic storage system that enables automated storage and retrieval of samples in cryogenic environments, as well as automated transfer of individual samples between cryogenic environments. Stored samples are maintained below a cryogenic temperature threshold while remaining accessible. Samples can be organized and tracked by scanning their individual barcodes. Embodiments may also include multiple storage containers and provide transfer of individual samples between these containers and between the storage containers and a removable cryogenic storage device.
Owner:AZENTA US INC
System and method for remotely monitoring cryogenic processing of sample
PendingCN121012824ALighting and heating apparatusPreparing sample for investigationEngineeringRemote sensing
A remote system for monitoring and controlling one or more devices for use in cryogenic processing of a sample is provided. A remote server (130) is provided that is capable of transmitting freezing curve data to one or more freezers (101,..., 10n), transmitting transport curve data to one or more transport devices, and transmitting thawing curve data to one or more thawing devices. The remote server is also capable of receiving detected data from the one or more freezers relating to freezing of the sample according to the freezing profile data, receiving detected data from the one or more transport devices relating to transport of the sample according to the transport profile data, and receiving detected data from the one or more thawing machines relating to thawing of the sample according to the thawing curve data.
Owner:BIOSAFE SA
Laboratory storage cabinet with a rotary element in a transfer air lock
Owner:HAMILTON STORAGE GMBH
Modular distributed cryogenic system
A modular distributed cryogenic distribution system, comprising: a common chamber housing cryogenic fluid conduits; and a plurality of cryochambers connected to the common chamber. A method of operating a modular distributed cryogenic distribution system comprising a common chamber housing cryogenic fluid conduits, and plural cryochambers connected to the common chamber, includes raising one the plurality of cryochambers room temperature while a second one of the plurality of cryochambers operates at a cryogenic temperature.
Owner:PSIQUANTUM CORP
Systems and methods for remotely monitoring the cryogenic processing of samples
A remote system for monitoring and controlling one or more devices for use in the cryogenic processing of a sample 100, 111, 112 ... 11n is provided. A remote server 50, 130 capable of transmitting freezing profile data to one or more freezers 10, 100, 101, 102 ... 10n, transmitting transportation profile data to one or more transportation devices 440, 500, and transmitting thawing profile data to one or more thawing devices. The remote server 50, 130 is also capable of receiving detected data from the one or more freezers 10, 100, 101, 102 ... 10n relating to the freezing of a sample 100, 111, 112 ... 11n in accordance with the freezing profile data, receiving detected data from the one or more transportation devices 440, 500 relating to the transportation of a sample 100, 111, 112 ... 11n in accordance with the transportation profile data, and receiving detected data from the one or more thawing machines relating to the thawing of a sample 100, 111, 112 ... 11n in accordance with the thawing profile data.
Owner:BIOSAFE SA
Automated depot module
PendingCN121201626ALighting and heating apparatusPreparing sample for investigationBarcodeProcess engineering
Cryogenic storage systems are provided that provide automated storage and retrieval of samples in cryogenic environments, as well as automated transfer of individual samples between cryogenic environments. The stored samples are maintained below a cryogenic temperature threshold while also being accessible. The samples can be neatened and tracked by scanning the barcodes of the samples. Embodiments may also include a plurality of storage reservoirs and provide for transfer of individual samples between the storage reservoirs and between the storage reservoir and the removable cryogenic storage device.
Owner:AZENTA US INC
Low-temperature vacuum plug rod with isolation cavity and core component rewarming method
The low-temperature vacuum inserting rod with an isolation cavity comprises an isolation cavity assembly and an inserting rod assembly; the isolation cavity assembly comprises a sealing assembly, a temperature recovery assembly, a suction flange and a vacuum valve, the sealing assembly is in sealing connection with the temperature recovery assembly, the temperature recovery assembly is in sealing connection with the vacuum valve, and the suction flange is connected with the temperature recovery assembly; the inserting rod assembly comprises a top end sealing plug, a feeder pipe and a bottom end sealing plug; the top end sealing plug and the bottom end sealing plug are respectively connected with two ends of the feeder pipe; the inserting rod assembly is located in the isolation cavity assembly and moves along the vertical direction of the isolation cavity assembly to an upper work position and a lower work position; when being in the upper work position and the lower work position, the top end sealing plug and the bottom end sealing plug respectively form a sealing structure with the sealing assembly. The application further discloses a core component temperature recovery method. The application has the advantages of not needing to be equipped with a heating temperature control loop, simplifying equipment, saving cost and fast temperature recovery.
Owner:UNIV OF SCI & TECH OF CHINA
Apparatus and method for producing microdroplets by freezing capillary
The application provides a device and a method for generating microdroplets by freezing a capillary tube, comprising a thermostat, a vertically placed glass capillary tube connected to the thermostat through a fixing device, and a liquid collecting box placed below the glass capillary tube. The fixing device comprises a base, a vertical guide rail and a capillary tube clamp connected in sequence, the liquid collecting box is placed on the base, and the capillary tube clamp clamps the glass capillary tube so that the glass capillary tube is located above the liquid collecting box. The application absorbs liquid into the glass capillary tube through capillary tension, vertically places the glass capillary tube above the liquid collecting device, gradually reduces the ambient temperature to-40 DEG C, and forms microdroplets under the action of the end gas-liquid interface tension due to the expansion of the liquid when the liquid is frozen and the extrusion bulging caused by the volume expansion of the liquid when the liquid is frozen. The liquid in the glass capillary tube starts to freeze and drops from the lower end to obtain microdroplets.
Owner:NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
Biochip for cryopreservation or thawing and resuscitation of biological tissue
Disclosed in the present invention is a biochip for cryopreservation or thawing and resuscitation of biological tissue, with four ends of the biochip being of a closed structure. The biochip includes: a section region, which is arranged in the middle and includes a plurality of sequentially arranged sections, with partition plates being provided between the sections, and the bottom of each section being provided with a fixing groove; and joint portions arranged on two sides of the section region. In the biochip having four ends being of a closed structure as provided in the present invention, a hydrogel or solution can be encapsulated in the plurality of sections of the biochip, such that the device is simple to operate and can effectively improve the efficiency of cryopreservation or thawing and resuscitation of embryos.
Owner:SHEN ZHEN BIOROCKS BIOTECHNOLOGY CO LTD
Vessels, devices, processes, and systems for tracking and managing items with circuitous custody chains
PendingEP4457029A4Air-pressure/air-lock chambersVaccination/ovulation diagnosticsEngineeringChain of custody
The approach disclosed herein can provide a closed-loop physical supply chain using a precision vessel. An example vessel includes an outer shell and an inner chamber that fits therein. The inner chamber includes a first compartment to removably house a product, and a second compartment with environmental control mechanisms. An enclosed layer, which may be secured to or integrated with the inner chamber, includes a controller and a communication interface to communicate with devices external to the precision vessel. Multiple sensors that monitor the first compartment send signals to the controller of the enclosed layer. A locking mechanism, when engaged, secures the outer shell to the inner chamber, and when disengaged, unlocks the outer shell from the inner chamber to thereby provide access to the first compartment and the product therein. The vessel can track its conditions and locations, and requires verification prior to disengaging the locking mechanism.
Owner:MEMORIAL SLOAN KETTERING CANCER CENT +2
Low-temperature thermostat with large solid angle and optical system
PendingCN121446578ALighting and heating apparatusDomestic cooling apparatusOptic systemMechanical engineering
The invention discloses a low-temperature thermostat with a large solid angle and an optical system, the low-temperature thermostat can be used for trapping large-scale ions and atoms, an outer shell is provided with a first cavity and a second cavity which are communicated with each other, and at least part of the cavity wall of the second cavity is of a transparent structure; the first-stage shell is located in the outer shell and comprises a third cavity and a fourth cavity, the third cavity is located in the first cavity, at least part of the cavity wall of the fourth cavity is of a transparent structure, and the fourth cavity extends into the second cavity; the second-stage shell is located in the first-stage shell, the second-stage shell is provided with a sample cavity, the sample cavity extends into the fourth cavity, at least part of the cavity wall of the sample cavity is of a transparent structure, and the transparent area of the sample cavity, the transparent area of the fourth cavity and the transparent area of the second cavity are opposite. The outer shell, the first-stage shell and the sample cavity are transparent cavities which are arranged in a sleeved mode, so that the outer side of the outer shell has a large space for containing the ray machine equipment, the ray machine equipment does not need to be placed in the cryostat, the requirement of the ray machine equipment for low temperature resistance is lowered, and the cost of the ray machine equipment is reduced.
Owner:UNIV OF SCI & TECH OF CHINA +1
A gas meter air tightness testing device
ActiveCN120558482BDetection of fluid at leakage pointLighting and heating apparatusThermodynamicsGas meter
This invention discloses a gas meter airtightness testing device, specifically relating to the field of airtightness testing technology. It includes a test chamber, a standard gas meter, a gas meter under test, a pressurizing device, a valve assembly, and a pressure detection assembly. The valve assembly includes a pressure regulating valve, a venting valve, and a discharge valve. The gas outlet pipe of the standard gas meter is connected to the gas inlet pipe of the gas meter under test. The gas meter under test is placed in the test chamber. The venting valve is located on the connecting pipe of the gas outlet pipe of the gas meter under test. A leak detection assembly is also installed in the test chamber to detect whether there is gas leakage in the gas meter under test during the gradual cooling process of the test chamber. This invention can effectively simulate a low-temperature environment and test the airtightness of a diaphragm gas meter under low-temperature conditions. This allows for effective judgment of the actual quality of the diaphragm gas meter, providing more effective extreme characteristic testing data for diaphragm gas meters, which is beneficial for the continued research and design of diaphragm gas meters.
Owner:NINGBO JUFENG INSTR CO LTD
Biological safety protection system and method for deep hypothermia storage device
The invention discloses a biological safety protection system and method for deep hypothermia storage equipment, and relates to the technical field of deep hypothermia sample storage.The biological safety protection system comprises a cabin body and a first disinfection pipeline, the cabin body is used for containing the deep hypothermia storage equipment, and a sealing cabin door is arranged on the cabin body; a sample tube can be taken and placed from the deep hypothermia storage equipment by opening the sealing cabin door, and at least two first disinfection openings are further formed in the cabin body; the first disinfection pipeline is at least located in the cabin body, the end of the first disinfection pipeline is communicated with the first disinfection opening, an opening communicated with the interior of the cabin body is formed in the first disinfection pipeline, a first valve is arranged at the opening, and the outer side of the first disinfection opening is further sequentially communicated with a filter and an exhaust device; the filter is detachably arranged; the problem that the external environment is polluted by pathogens can be solved from multiple aspects, and the reliability is greatly improved.
Owner:BEIJING YIAN HUAMEI TECH CO LTD
Device for cooling a sample environment, sample holder and method for protecting a sample from vibration of a
PendingCN121420167APreparing sample for investigationCompression machinesHeat conductingRelative motion
Owner:REPRESENTATIVE INSTITUTION OF THE FREE STATE OF BAVARIA AT THE TECHNICAL UNIVERSITY OF MUNICH
Gas tightness detection device for gas meter
ActiveCN120558482ADetection of fluid at leakage pointLighting and heating apparatusGas meterGas leak
The invention discloses a gas meter airtightness detection device, and particularly relates to the technical field of airtightness detection, the gas meter airtightness detection device comprises a test box, a standard meter, a to-be-detected meter, a pressurization device, a valve assembly and a pressure detection assembly, the valve assembly comprises a pressure regulating valve, a deflation valve and a discharge valve, a gas outlet pipe of the standard meter is in butt joint with a gas inlet pipe of the to-be-detected meter, and the to-be-detected meter is arranged in the test box; the air release valve is arranged on a butt joint pipeline of an air outlet pipe of the to-be-tested meter, and an air leakage detection assembly is further arranged in the test box and used for detecting whether the to-be-tested meter leaks air or not in the process that the test box is gradually cooled. The low-temperature environment can be effectively simulated, the gas tightness of the diaphragm gas meter in the low-temperature environment can be tested, the actual quality of the diaphragm gas meter can be effectively judged, more effective limit characteristic detection data are provided for the diaphragm gas meter, and continuous research, development and design of the diaphragm gas meter are facilitated.
Owner:NINGBO JUFENG INSTR CO LTD
A skeletal muscle contraction response test device
The application relates to a skeletal muscle contraction response test device, and belongs to the technical field of medical instruments, which solves the problem that the placement position of a tension sensor is different each time test operation is performed, the tension of a pulling line cannot be finely adjusted, and test failure is easily caused in the prior art. The skeletal muscle contraction response test device comprises a reaction box, a pulling line and a measuring assembly, and the pulling line is connected with the reaction box and the measuring assembly respectively. The tensioner of the application can make the tension unit away from or close to the water bath assembly, increase or reduce the supporting force on the pulling line, further tighten or loosen the pulling line, finely adjust the tension of the pulling line, and ensure the test effect.
Owner:PEKING UNIVERSITY THIRD HOSPITAL (THE THIRD CLINICAL MEDICAL SCHOOL OF PEKING UNIVERSITY)
Freezing object storage device
PendingCN121219204ABioreactor/fermenter combinationsBiological substance pretreatmentsClassical mechanicsStructural engineering
Owner:MEDIPAL HLDG CORP
System for cryogenic storage
The present disclosure provides cryogenic storage systems and methods of using the cryogenic storage systems. A cryogenic storage system of the present disclosure may comprise a cryogenic tank with an inner door and an outer door, and a robot apparatus located adjacent to the cryogenic tank. The cryogenic tank may store multiple racks such that at most a single rack is removable through the inner door or the outer door. The cryogenic tank may store the multiple racks in multiple groups of racks comprising a first group of racks located at a first radial distance and a second group of racks located at a second radial distance that is greater than the first radial distance. The robot apparatus may selectively open and close the inner or outer doors, and insert or withdraw the single rack into or out of the cryogenic tank through the inner door or the outer door.
Owner:CELLTRIO INC
Cryogenic cooling system with active heat exchanger
The cryogenic cooling system comprises a dilution refrigerator, the dilution refrigerator having a mixing chamber (401), a fractionator (402), and a circulator for circulating the working fluid through the mixing chamber (401) and the fractionator (402). At least one active heat exchanger (408, 801, 802, 901) has a first end and a second end and is configured to use input energy to transfer heat from the first end to the second end during operation. The first end and the second end of the at least one active heat exchanger (408, 801, 802, 901) are thermally coupled at their respective positions along the circulator to transfer heat between the respective portions of the circulating working fluid.
Owner:ブルーフォース オイ
Low-vibration low-temperature high-intensity magnetic field optical thermostat based on pulse tube refrigerator
PendingCN121830485ACompression machinesMaterial analysis by optical meansPulse tube refrigeratorSuperconducting Coils
The low-vibration low-temperature high-magnetic-field optical thermostat comprises a vacuum cavity, a refrigerating machine assembly and a sample cavity assembly, a superconducting magnet surrounds the bottom of the sample cavity assembly, and a primary cold screen is arranged around the refrigerating machine assembly, the sample cavity assembly and the superconducting magnet; the superconducting magnet is provided with an optical channel leading to the sample cavity, a vacuum cavity window and a primary cold screen window are formed in the horizontal position, corresponding to the optical channel, of the vacuum cavity and the primary cold screen, the sample cavity assembly comprises a sample table, and sample cavity windows are formed in the periphery of the sample table in multiple directions. The vibration of the device is greatly reduced, the requirement of optical measurement on low-magnitude vibration amplitude in a low-temperature strong magnetic field environment is met, and meanwhile, the optical observation window and the lifting platform with multiple angles are arranged, so that the observation optical view field is expanded, and a sample is convenient to observe.
Owner:CSIC PRIDE (NANJING) CRYOGENIC TECHNOLOGY CO LTD
A multifunctional low-temperature precision measurement and test platform and method
The application discloses a multifunctional low-temperature precision measurement and test platform and method, and relates to the field of low-temperature precision measurement and sealed characteristic research.The application comprises a low-temperature thermostat with an internal vacuum, two test cavities with different functions, a GM refrigerator and other related test equipment installed on the low-temperature thermostat.The application overcomes the shortcomings of long experimental time, incapability of replacing parts in the middle of the experiment, large energy consumption, small test temperature zone and single test function of the prior art.The multifunctional low-temperature precision measurement platform can simulate the real working environment of a low-temperature system, and can experimentally study the sealing performance of a sealing material and the physical characteristics of various materials applied to the low-temperature system, so that the test result is reliable.
Owner:HEFEI INSTITUTE OF PHYSICAL SCIENCE CHINESE ACADEMY OF SCIENCES +1
Low-temperature and low-pressure adsorption performance testing device and testing method thereof
The invention discloses a low-temperature low-pressure adsorption performance testing device and a testing method thereof. The device comprises a vacuum container, a low-temperature unit, an adsorption unit, a gas distribution unit, a vacuum unit, a buffer unit and a data acquisition unit, the gas distribution unit independently provides working medium gas and test gas for the low-temperature unit and the adsorption unit; the low-temperature unit performs gradient pre-cooling on the working medium gas and the test gas; the adsorption unit is in heat-conducting connection with the low-temperature unit; the buffer unit is used for performing multi-stage pressure stabilization and flow control on the test gas; the vacuum unit is used for independently vacuumizing each unit; the data acquisition unit monitors pressure parameters. The test method comprises the following steps: vacuumizing to an initial high vacuum state, introducing working medium gas for refrigeration and temperature stabilization, carrying out gradient pre-cooling on test gas, carrying out multi-stage pressure stabilization, introducing the test gas into the adsorption unit, recording balance pressure data, and calculating the adsorption quantity. According to the invention, a stable low-temperature environment can be provided for adsorption performance testing, refrigeration vibration interference is isolated, and the stability of adsorption testing is improved.
Owner:ZHEJIANG UNIV CITY COLLEGE
Automated vault module
ActiveUS12631531B2Lighting and heating apparatusPreparing sample for investigationBarcodeMechanical engineering
Cryogenic storage system provides automated storage and retrieval of samples in a cryogenic environment, as well as automated transfer of individual samples between cryogenic environments. Stored samples are maintained under a cryogenic temperature threshold, while also enabling access to the samples. The samples may be organized and tracked by scanning a barcode of each sample. The system may also comprise multiple storage vaults and provide for transfer of individual samples between the storage vaults, as well as between a storage vault and a removable cryogenic storage device.
Owner:AZENTA US INC