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Apparatus to facilitate transfer of biological specimens stored at cryogenic conditions
ActiveUS12290816B2Dead animal preservationCo-operative working arrangementsSoftware engineeringSpecimen containers
A system and method facilitates transfers of specimen containers (e.g., vials with caps) between storage cassettes and carrier cassettes. The storage cassettes are designed to be stored in cryogenic refrigerators while the carrier cassettes are designed to be temporarily stored in a portable carrier. Identification information is read from wireless transponders carried by the specimen containers. Visual mappings of the positions of the specimen container in the cassettes is provided. Presence and position of the specimen containers in the cassettes is verified, and alerts of inconsistencies provided along with corrective commands. Inventories of specimen container and even specific specimen holders are provided.
Owner:TMRW LIFE SCIENCES INC
Modular distributed cryogenic system
A modular distributed cryogenic distribution system, comprising: a common chamber housing cryogenic fluid conduits; and a plurality of cryochambers connected to the common chamber. A method of operating a modular distributed cryogenic distribution system comprising a common chamber housing cryogenic fluid conduits, and plural cryochambers connected to the common chamber, includes raising one the plurality of cryochambers room temperature while a second one of the plurality of cryochambers operates at a cryogenic temperature.
Owner:PSIQUANTUM CORP
Systems, apparatus and methods to pick and / or place specimen containers
ActiveUS12527318B2Lighting and heating apparatusStationary refrigeration devicesControl systemHydrology
A system, device and method to pick and / or place specimen containers may include a pick and / or place head, a first secondary reservoir, and optionally a second secondary reservoir which hold cryogenic fluid in a liquid form, above a main reservoir of cryogenic liquid, to cool the pick and / or place head and / or to cool or recharge the specimen containers during transfer operations. Storage locations may be arrayed in wedge-shaped sets spaced above cryogenic liquid of the main reservoir of a cryogenic storage tank at one or more levels, and pivotal about a central axis via a motor and control system. A gap (e.g., wedge shaped gap) between two successively angularly adjacent sets of storage locations of the sets of storage locations at an upper level provides access to the storage locations of the sets of storage locations at a lower level. Cryogenic liquid temperatures and levels in reservoirs are monitored.
Owner:TMRW LIFE SCIENCES INC
Vessels, devices, processes, and systems for tracking and managing items with circuitous custody chains
PendingUS20250065334A1Vaccination/ovulation diagnosticsLaboratory glasswaresCommunication interfaceControl engineering
The approach disclosed herein can provide a closed-loop physical supply chain using a precision vessel. An example vessel includes an outer shell and an inner chamber that fits therein. The inner chamber includes a first compartment to removably house a product, and a second compartment with environmental control mechanisms. An enclosed layer, which may be secured to or integrated with the inner chamber, includes a controller and a communication interface to communicate with devices external to the precision vessel. Multiple sensors that monitor the first compartment send signals to the controller of the enclosed layer. A locking mechanism, when engaged, secures the outer shell to the inner chamber, and when disengaged, unlocks the outer shell from the inner chamber to thereby provide access to the first compartment and the product therein. The vessel can track its conditions and locations, and requires verification prior to disengaging the locking mechanism.
Owner:MEMORIAL SLOAN KETTERING CANCER CENT +2
Defrost fan control
A refrigeration module of a cold space chamber has a blower and an evaporator. A method of controlling the refrigeration module includes defrosting a coil of the evaporator to form a volume of warm air surrounding the coil. The method includes circulating a refrigerant through the evaporator after defrosting the coil, to cool the coil. The method includes operating the blower in a series of pulses to control introduction of the volume of warm air into the cold space chamber.
Owner:TRANE TECHNOLOGIES LIFE SCIENCES LLC
Systems, devices, and methods for automated thawing of bag-format storage vessels
The present invention discloses sample thawing devices, systems, and methods, that are configured to take bag-format sample vessels, referred to as “cryobags”, and to thaw the contents of such cryobags. The contents of such cryobags are samples with cells, and the thawing of such samples is based on the temperature, volume, and mass of the sample in order to evenly distribute heat and avoid ice crystallization damage to the cells during thawing. Paired heater plates form an assembly configured to support, clamp, and thaw individual cryobags. The heater plate pair has an articulated member that is repositioning to provide for ease in inserting and removing samples.
Owner:BIOLIFE SOLUTIONS INC
A module for a freeze-dryer system, a freeze-dryer system and a method for using the system
PCT designated stageWO2025158039A1Drying solid materials with heatDrying solid materials without heatFreeze-dryingControl cell
The present invention is related to a sample heat exchanger module (200) for a freeze-dryer system (100) comprising - a first heat exchange element (201) made of thermally conductive material and comprising • a top surface (202); and • a plurality of straight passages (203, 204, 205) extending in different directions through the first heat exchange element (201), the passages being parallel to the top surface (202) and intersecting at the interior of the first heat exchange element (201); - a first cold source (206) comprising a cold end (207) with a maximum efficiency zone (208) that is in thermal contact with the first heat exchange element (201); and - a first heat source (209) comprising a maximum efficiency zone (210) in thermal contact with the first heat exchange element (201); wherein the straight passages (203, 204, 205) are arranged between the top surface (202) and the maximum efficiency zones (208, 210) of the first cold source (206) and the first heat source (209), and wherein the first cold source (206) and the first heat source (209) are controllable by a control unit (102) to decrease or increase the temperature of the first heat exchange element (201).
Owner:300K SOLUTIONS SL
Rapid-cooling, temperature-intensive cryogenic test chamber allowing for relative motion
PendingUS20250283792A1Preparing sample for investigationMaterial strength using tensile/compressive forcesTest chamberRelative motion
A cryogenic testing apparatus includes a housing in which a cryogenic chamber is positioned. An upper channel is arranged around the cryogenic chamber and is configured to receive a cryogen. A lower channel is arranged below the upper channel and is configured to receive cryogen from the upper channel. As the cryogen flows through the cryogenic testing apparatus, the cryogen contacts an exterior of the cryogenic chamber. The cryogenic chamber is unsealed and is configured to receive a gas to create positive pressure within the cryogenic chamber.
Owner:TEXAS A&M UNIVERSITY +1
Accommodation apparatus for freezing target
To increase the quantity of freezing targets stored in a storage space of a freezing container. A first accommodation unit 10 accommodating a first freezing target 91 includes a first female screw member 16a to which a part of a shaft member 80A is detachably coupled. A second accommodation unit 20 accommodating a second freezing target 92 includes a second female screw member 26a to which a part of the shaft member 80A is detachably coupled, and is arranged above the first accommodation unit 10 in a state of being stored in a freezing container 300. In a state where the second accommodation unit 20 is arranged above the first accommodation unit 10, the shaft member 80A is coupled to the first female screw member 16a to take out the first accommodation unit 10 and the second accommodation unit 20 collectively.
Owner:MEDIPAL HLDG CORP
Thermal Connection Assemblies and Methods
PendingUS20250123049A1Lighting and heating apparatusPreparing sample for investigationThermodynamicsProcess engineering
Cryogenic analysis systems are provided that can include: a cryogenic fluid source component; an analysis component; and a thermal connection assembly operably engaged with both the cryogenic fluid source component and the analysis component to provide disengagement or engagement of the cryogenic fluid source component to / from the analysis component while maintaining the cooling status of the cryogenic fluid source component. Methods for performing sample analysis under cryogenic conditions are provided, the methods comprising: providing an analysis component; providing a cryogenic fluid source component having cryogenic fluid in a cold state; operably engaging the analysis component and the cryogenic fluid source component; preparing a sample for analysis within the analysis component; and while maintaining the cryogenic fluid in the cold state, disengaging the cryogenic fluid source component from the analysis component.
Owner:MONTANA INSTRUMENTS CORP
Rapid-cooling, temperature-intensive cryogenic test chamber allowing for relative motion
PendingEP4515203A1Preparing sample for investigationMaterial strength using tensile/compressive forces
A cryogenic testing apparatus includes a housing in which a cryogenic chamber is positioned. An upper channel is arranged around the cryogenic chamber and is configured to receive a cryogen. A lower channel is arranged below the upper channel and is configured to receive cryogen from the upper channel. As the cryogen flows through the cryogenic testing apparatus, the cryogen contacts an exterior of the cryogenic chamber. The cryogenic chamber is unsealed and is configured to receive a gas to create positive pressure within the cryogenic chamber.
Owner:TEXAS A&M UNIVERSITY +1
Method for lyophilization and device thereof
PendingUS20260175219A1Preparing sample for investigationLaboratory glasswaresEngineeringBiochemistry
Owner:ARGONAUT MFG SERVICES INC
Container unit and specimen-cooling device comprising same
PCT designated stage expiredWO2025100636A1Preparing sample for investigationLaboratory glasswaresPhysicsCooling Units
Owner:SAMSUNG MEDICAL CENT
Modular distributed cryogenic system
A modular distributed cryogenic distribution system, comprising: a common chamber housing cryogenic fluid conduits; and a plurality of cryochambers connected to the common chamber. A method of operating a modular distributed cryogenic distribution system comprising a common chamber housing cryogenic fluid conduits, and plural cryochambers connected to the common chamber, includes raising one the plurality of cryochambers room temperature while a second one of the plurality of cryochambers operates at a cryogenic temperature.
Owner:PSIQUANTUM CORP
Control system for a liquid filling level and microscope stage including such a system
A system for controlling a filling level of a reservoir filled with a liquid includes the reservoir configured to be filled with the liquid at least up to a maximum filling level. The system also includes a probe including a probe body, at least a section of the probe body extending, in a height dimension of the reservoir, from a first position to a second position, the first position being lower than the second position, and the second position being above the maximum filling level, and further including a temperature dependent sensor configured to generate a sensor signal based on a temperature at the second position, the temperature depending on the filling level. The system also includes a controller for controlling the filling level of the reservoir depending on the sensor signal such that the filling level is kept constant.
Owner:LEICA MIKROSYSTEME GMBH
Automated storage module
ActiveCN114814260BLighting and heating apparatusPreparing sample for investigationBarcodeProcess engineering
This invention provides a cryogenic storage system that enables automated storage and retrieval of samples in cryogenic environments, as well as automated transfer of individual samples between cryogenic environments. Stored samples are maintained below a cryogenic temperature threshold while remaining accessible. Samples can be organized and tracked by scanning their individual barcodes. Embodiments may also include multiple storage containers and provide transfer of individual samples between these containers and between the storage containers and a removable cryogenic storage device.
Owner:AZENTA US INC
Method and apparatus for preservation of biological material
Owner:VITRAFY LIFE SCI LTD
Modular distributed cryogenic system
A modular distributed cryogenic distribution system, comprising: a common chamber housing cryogenic fluid conduits; and a plurality of cryochambers connected to the common chamber. A method of operating a modular distributed cryogenic distribution system comprising a common chamber housing cryogenic fluid conduits, and plural cryochambers connected to the common chamber, includes raising one the plurality of cryochambers room temperature while a second one of the plurality of cryochambers operates at a cryogenic temperature.
Owner:PSIQUANTUM CORP
In-vitro diagnostic reagent card incubation device
The invention discloses an in-vitro diagnostic reagent card incubation device, and belongs to the technical field of medical instruments, the in-vitro diagnostic reagent card incubation device comprises an incubation disc, a heating film is arranged on the top surface of the incubation disc, a heating film pressing plate is arranged on the top surface of the heating film, a plurality of incubation grooves used for inserting reagent cards are formed in the peripheral surface of the incubation disc, and the incubation disc is provided with an incubation cavity. A push block is arranged in the incubation groove, and a driving piece for driving the push block to move is arranged in the incubation groove. The device has the effect that a worker can conveniently take out the incubated reagent card.
Owner:BEIJING HUAYI JINGDIAN BIOTECHNOLOGY CO LTD
System and method for remotely monitoring cryogenic processing of sample
PendingCN121012824ALighting and heating apparatusPreparing sample for investigationEngineeringRemote sensing
A remote system for monitoring and controlling one or more devices for use in cryogenic processing of a sample is provided. A remote server (130) is provided that is capable of transmitting freezing curve data to one or more freezers (101,..., 10n), transmitting transport curve data to one or more transport devices, and transmitting thawing curve data to one or more thawing devices. The remote server is also capable of receiving detected data from the one or more freezers relating to freezing of the sample according to the freezing profile data, receiving detected data from the one or more transport devices relating to transport of the sample according to the transport profile data, and receiving detected data from the one or more thawing machines relating to thawing of the sample according to the thawing curve data.
Owner:BIOSAFE SA
Laboratory storage cabinet with rotor in transport airlock
The present invention relates to a laboratory storage cabinet (10) including a cabinet housing (12) separating a storage space (14) within the cabinet housing (12) from an environment (U) external to the storage cabinet (12), the cabinet housing (12) including an airlock (20) that allows transport of materials between an inner transport position located within the storage space (14) and an outer transport position located within the outer environment (U), a storage device (28) within the storage space (14) for receiving materials at a predetermined storage position, and a handling device (26) within the storage space (14) for transporting materials between the inner transport position and the storage device (26), and the airlock (20) having an airlock opening (24) in a wall (12a) of the cabinet housing (12), the airlock opening penetrating the wall (12a). According to the present invention, the airlock (20) includes a rotor (22) having at least one loading structure (44) rotatably mounted relative to the cabinet housing (12) about a rotation axis (R), the rotor being fitted into the airlock opening (24) such that the loading structure (44) is displaceable between an inner transport position and an outer transport position by rotation of the rotor (22) about the rotation axis (R).
Owner:HAMILTON STORAGE GMBH
Laboratory storage cabinet with a rotary element in a transfer air lock
Owner:HAMILTON STORAGE GMBH
Modular distributed cryogenic system
A modular distributed cryogenic distribution system, comprising: a common chamber housing cryogenic fluid conduits; and a plurality of cryochambers connected to the common chamber. A method of operating a modular distributed cryogenic distribution system comprising a common chamber housing cryogenic fluid conduits, and plural cryochambers connected to the common chamber, includes raising one the plurality of cryochambers room temperature while a second one of the plurality of cryochambers operates at a cryogenic temperature.
Owner:PSIQUANTUM CORP
Systems and methods for remotely monitoring the cryogenic processing of samples
A remote system for monitoring and controlling one or more devices for use in the cryogenic processing of a sample is provided. A remote server (130) is provided, capable of transmitting freezing profile data to one or more freezers (101, . . . , 10n), transmitting transportation profile data to one or more transportation devices, and transmitting thawing profile data to one or more thawing devices. The remote server is also capable of receiving detected data from the one or more freezers relating to the freezing of a sample in accordance with the freezing profile data, receiving detected data from the one or more transportation devices relating to the transportation of a sample in accordance with the transportation profile data, and receiving detected data from the one or more thawing machines relating to the thawing of a sample in accordance with the thawing profile data.
Owner:BIOSAFE SA
Systems and methods for remotely monitoring the cryogenic processing of samples
A remote system for monitoring and controlling one or more devices for use in the cryogenic processing of a sample 100, 111, 112 ... 11n is provided. A remote server 50, 130 capable of transmitting freezing profile data to one or more freezers 10, 100, 101, 102 ... 10n, transmitting transportation profile data to one or more transportation devices 440, 500, and transmitting thawing profile data to one or more thawing devices. The remote server 50, 130 is also capable of receiving detected data from the one or more freezers 10, 100, 101, 102 ... 10n relating to the freezing of a sample 100, 111, 112 ... 11n in accordance with the freezing profile data, receiving detected data from the one or more transportation devices 440, 500 relating to the transportation of a sample 100, 111, 112 ... 11n in accordance with the transportation profile data, and receiving detected data from the one or more thawing machines relating to the thawing of a sample 100, 111, 112 ... 11n in accordance with the thawing profile data.
Owner:BIOSAFE SA
Automated depot module
PendingCN121201626ALighting and heating apparatusPreparing sample for investigationBarcodeProcess engineering
Cryogenic storage systems are provided that provide automated storage and retrieval of samples in cryogenic environments, as well as automated transfer of individual samples between cryogenic environments. The stored samples are maintained below a cryogenic temperature threshold while also being accessible. The samples can be neatened and tracked by scanning the barcodes of the samples. Embodiments may also include a plurality of storage reservoirs and provide for transfer of individual samples between the storage reservoirs and between the storage reservoir and the removable cryogenic storage device.
Owner:AZENTA US INC
Low-temperature vacuum plug rod with isolation cavity and core component rewarming method
The low-temperature vacuum inserting rod with an isolation cavity comprises an isolation cavity assembly and an inserting rod assembly; the isolation cavity assembly comprises a sealing assembly, a temperature recovery assembly, a suction flange and a vacuum valve, the sealing assembly is in sealing connection with the temperature recovery assembly, the temperature recovery assembly is in sealing connection with the vacuum valve, and the suction flange is connected with the temperature recovery assembly; the inserting rod assembly comprises a top end sealing plug, a feeder pipe and a bottom end sealing plug; the top end sealing plug and the bottom end sealing plug are respectively connected with two ends of the feeder pipe; the inserting rod assembly is located in the isolation cavity assembly and moves along the vertical direction of the isolation cavity assembly to an upper work position and a lower work position; when being in the upper work position and the lower work position, the top end sealing plug and the bottom end sealing plug respectively form a sealing structure with the sealing assembly. The application further discloses a core component temperature recovery method. The application has the advantages of not needing to be equipped with a heating temperature control loop, simplifying equipment, saving cost and fast temperature recovery.
Owner:UNIV OF SCI & TECH OF CHINA
A multi-station constant temperature device for measuring Henry's constant of methane in water
InactiveCN113866374BCryostatsTesting organic contamination in waterTemperature controlHeating effect
The present invention discloses a multi-station constant temperature device for measuring Henry's constant of methane in water, comprising a heat preservation box, an induction temperature control mechanism and a heating mechanism arranged inside the heat preservation box, a heat preservation chamber is formed inside the heat preservation box, the induction temperature control mechanism is arranged in the heat preservation chamber, and the heating mechanism is arranged in the side wall of the heat preservation box; wherein, a plurality of the heat preservation boxes connect a plurality of the heat preservation chambers, and the heating mechanism forms a new heating path during the connection process of the plurality of the heat preservation boxes. The invention realizes that the number of the heat preservation boxes changes with the number of equipment that needs to be insulated when in use, thereby increasing the scope of use and reducing the floor space occupied by the heat preservation device; and when a plurality of heat preservation chambers are connected, the water temperatures in the plurality of heat preservation boxes are ensured to be the same, thereby improving the accuracy of the control variable; and the heating area is increased, thereby improving the heating effect.
Owner:GUANGZHOU MARINE GEOLOGICAL SURVEY +2
Low temperature specimen carriers
A specimen carrier includes an elongate member defining an external sealing surface and a support surface upon which a specimen can be carried, the elongate member including a first material having a first coefficient of thermal expansion. The specimen carrier further includes a cap configured to be passed over a portion of the elongate member to close a region of the cap that surrounds the specimen when the cap is passed over the portion of the elongate member, the cap defining an internal sealing surface formed complementary to the external sealing surface, and the cap including a second material having a second coefficient of thermal expansion that is greater than the first coefficient of thermal expansion. When the elongate member and cap are together placed in a cooling substance, the internal sealing surface of the cap compresses the external sealing surface of the elongate member to form a hermetic seal.
Owner:COOPERSURGICAL INC
Apparatus and method for producing microdroplets by freezing capillary
The application provides a device and a method for generating microdroplets by freezing a capillary tube, comprising a thermostat, a vertically placed glass capillary tube connected to the thermostat through a fixing device, and a liquid collecting box placed below the glass capillary tube. The fixing device comprises a base, a vertical guide rail and a capillary tube clamp connected in sequence, the liquid collecting box is placed on the base, and the capillary tube clamp clamps the glass capillary tube so that the glass capillary tube is located above the liquid collecting box. The application absorbs liquid into the glass capillary tube through capillary tension, vertically places the glass capillary tube above the liquid collecting device, gradually reduces the ambient temperature to-40 DEG C, and forms microdroplets under the action of the end gas-liquid interface tension due to the expansion of the liquid when the liquid is frozen and the extrusion bulging caused by the volume expansion of the liquid when the liquid is frozen. The liquid in the glass capillary tube starts to freeze and drops from the lower end to obtain microdroplets.
Owner:NANJING UNIV OF AERONAUTICS & ASTRONAUTICS