The invention discloses a portable remote 12-lead electrocardiogram real-time diagnosis system comprising a data acquisition box, an integrated multi-lead electrode plate and a smartphone. The system is simple in structure, lower in price and good in portability, a patient can diagnose electrocardio movement in real time according to requirement of symptoms, and the problem that electrocardiogram in hospitals cannot capture electrocardio conditions during attacks outside the hospitals is solved; waiting is not required, the integrated multi-lead electrode plate is disposable, distribution of precordial lead electrodes on the electrode plate takes body surface markers such as nipples on two sides of human bodies, sternums and the like as reference points, operation by non-medical workers is facilitated, great convenience is brought, meanwhile, the possibility of infectious skin disease cross infection is avoided; the integrated multi-lead electrode plate is attached to the chest and cannot bring inconvenience to the life of the patient, electrocardiograms are transferred to a hospital terminal to be analyzed and diagnosed by doctors for real-time report, the electrocardio conditions can be accurately judged, the diagnosis accuracy is improved, and the using effect is good.