11 results about "Buprenophine" patented technology

Disclosed herein is deuterated buprenorphine as a protective agent for fetal subjects against full-agonist opioid exposure. Use of deuterated buprenorphine prevents or reduces exposure of the fetus to opioids used by the mother. Use of deuterated buprenorphine may prevent or reduces exposure of the fetus to harmful metabolites of buprenorphine.

This disclosure provides a method for treating a disease in a subject requiring treatment, such as chronic pain or IBS-D, the method of treating the disease by orally administering i) a therapeutically effective amount of buprenorphine dimer, or ii) a pharmaceutical composition comprising a therapeutically effective amount of buprenorphine dimer, wherein the buprenorphine dimer is represented by formula (I) or a pharmaceutically acceptable salt thereof. In particular, the administered buprenorphine dimer of formula (I) is in a neutral form. A method for producing a neutral form of buprenorphine dimer is also described.

The present disclosure provides a method of treating a disease (e.g., chronic pain or IBS-D) in a subject in need thereof by oral administration: i) a therapeutically effective amount of buprenorphine dimer; or ii) a pharmaceutical composition comprising a therapeutically effective amount of the buprenorphine dimer wherein the buprenorphine dimer is represented by Formula (I): or a pharmaceutically acceptable salt thereof, in particular, the administered buprenorphine dimer of Formula (I) is in a neutral form, methods of preparing the buprenorphine dimer in neutral form are also described.

Disclosed in certain embodiments is a method of treating or preventing an opioid-induced adverse pharmacodynamic response comprising administering to a patient in need thereof an effective amount of buprenorphine.

Disclosed herein are methods that may be used for the synthesis of benzylisoquinoline alkaloids (“BIAs”) such as alkaloid morphinan. The methods disclosed can be used to produce thebaine, oripavine, codeine, morphine, oxycodone, hydrocodone, oxymorphone, hydromorphone, naltrexone, naloxone, hydroxycodeinone, neopinone, and / or buprenorphine. Compositions and organisms useful for the synthesis of BIAs, including thebaine synthesis polypeptides, purine permeases, and polynucleotides encoding the same, are provided.

The invention discloses a preparation method of a buprenorphine hydrochloride key intermediate, particularly provides an improved method for preparing 7 alpha [(S)-1-hydroxy-1, 2, 2-trimethylpropyl]-6, 14-diethylidene-6, 7, 8, 14-tetrahydrothebaine, and belongs to the technical field of medical intermediates. The compound is a key intermediate for synthesizing buprenorphine hydrochloride. The solid of the key intermediate is obtained with high yield and high purity through the method, and the method is simple and convenient to operate and suitable for industrial production.

The invention discloses a preparation method and intermediates of various opioid drugs. The invention provides a preparation method of various opioid drugs, and particularly provides a preparation method of a compound as shown in a formula A7 and a series of compounds as shown in a formula A6-2 and the like, the preparation method comprises the following steps: S10, under the action of a cyclization reagent, the compound as shown in the formula A6-2 is subjected to a cyclization reaction as shown in the following formula in an organic solvent, and the compound as shown in the formula A6-2 is obtained. The compound as shown in the formula A7 is obtained. A series of intermediates provided by the invention can be used for divergently synthesizing a plurality of opioid medicines, including naltrexone, nalmefene, nalbuphine, buprenorphine and the like. The preparation method provided by the invention has one or more of the following advantages: cheap and easily available raw materials, short synthesis steps, simple operation, easily amplified process and high product yield.

The disclosure provides a dosage regimen using sustained-release buprenorphine formulations to produce therapeutic levels of buprenorphine in patients for the treatment of pain or opioid use disorders.

Disclosed in the present invention are a preparation method for various opioids and intermediates thereof. Provided in the present invention is a preparation method for various opioids. Specifically, provided are a preparation method for a compound represented by formula A7 and a series of compounds, such as a compound represented by formula A6-2. The preparation method comprises the following step: S10: subjecting a compound represented by formula A6-2 to a cyclization reaction represented by the following formula in an organic solvent under the action of a cyclization reagent, so as to obtain a compound represented by formula A7. A series of intermediates provided by the present invention enables the divergent synthesis of various opioids, including naltrexone, nalmefene, nalbuphine, buprenorphine, etc. The preparation method provided by the present invention has one or more of the following advantages: cheap and readily available raw materials, short synthetic steps, simple operation, easy scale-up of the process, and a high product yield.