The invention discloses an access control method and system based on a Bluetooth MESH networking core technology. The system comprises a CPU main control chip module, a Bluetooth wireless networking module, a door lock electric control module, a keyboard input module and a power supply module. The method comprises the following steps: accessing lower-layer Bluetooth terminal equipment by utilizing Bluetooth module communication, and realizing point-to-point unlocking control and real-time feedback of door lock status information; connecting with other Bluetooth door locks and a Bluetooth gateway through the Bluetooth module communication, constructing an MESH network layer, realizing MESH route management, and carrying out information multi-hop transmission, so that a locking/unlocking control command pushed by a remote receiving server, server-side user right or door lock information change and a function of uploading local door lock status information through a Bluetooth MESH network are realized; and manually intervening unlocking by inputting a spare dynamic password by virtue of a keyboard, wherein the spare dynamic password can be set with a valid period at a server side according to the need, and safety and convenience of a door lock are guaranteed.