The invention provides a method for detecting spherical decode based on depth-first search, which comprises the following steps: A, performing QR deposition on a channel matrix; B, multiplying a conjugate transpose and a received signal of a Q matrix to obtain an equalizing signal rho; C, setting an initial search radius; D, executing the depth-first search according to the initial search radius, an R matrix and the rho, and updating the search radius; E, setting an upper limit value M of the search total node number and an upper limit value Ki of the ith layer search node number; F, executing the depth-first search according to the current search radius, the R matrix and the rho, and when the search gets to the ith layer, judging whether the searched node number on the ith layer is equal to Ki or not, otherwise, executing the search on the ith layer, and if so, getting to search the i+1th layer; and G, repeating the step F until the searched total node number is equal to M or all the layers cannot be searched any more, and outputting a decoding result. The method can effectively reduce the operation complexity of the sphere decoding, and is easy to achieve through hardware.