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382results about How to "Type of reduction" patented technology

Gene expression profile biomarkers and therapeutic targets for brain aging and age-related cognitive impairment

A statistical and functional correlation strategy to identify changes in cellular pathways specifically linked to impaired cognitive function with aging. Analyses using the strategy identified multiple groups of genes expressed in the hippocampi of mammals, where the genes were expressed at different levels for several ages. The aging changes in expression began before mid-life. Many of the genes were involved in specific neuronal and glial pathways with previously unrecognized relationships to aging and/or cognitive decline. The processes identified by the strategy suggest a new hypothesis of brain aging in which initially decreased neuronal activity and/or oxidative metabolism trigger separate but parallel genomic cascades in neurons and glia. In neurons, the cascade results in elevations in calcium signaling and reductions of immediate early gene signaling, biosynthesis, synaptogenesis and neurite remodeling. In contrast, glia undergo increased lipid metabolism and mediate a cycle of demyelination and remyelination that induces antigen presentation, inflammation, oxidative stress and extracellular restructuring. These identified genes and the proteins they encode can be used as novel biomarkers of brain aging and as targets for developing treatment methods against age-related cognitive decline, Alzheimer's Disease and Parkinson's Disease.
Owner:UNIV OF KENTUCKY RES FOUND

Building industrialization concrete horizontal structure prefabricated part application primary design method

The invention discloses a building industrialization concrete horizontal structure prefabricated part application primary design method. A general 'standard superposed beam selection parameter and corresponding number table', various forms of 'bending, shearing and twisting reinforcing bar number combination tables' of superposed floor beams of different concrete grades and section sizes, a 'horizontal prefabricated concrete superposed floor beam standard schematic handbook', a general 'standard superimposed floor slab selection parameter and corresponding number table', a 'horizontal prefabricated superposed floor beam standard graph parameter database', a 'horizontal prefabricated superimposed floor slab standard graph parameter database' and the like are compiled, and are matched with parameters, a software module and a computing result of horizontal structure prefabricated part application primary design software adapted from building structure analysis design software. Through adoption of the method, the design, prefabrication and installation application costs of a novel building industrialization structural part can be lowered, and the bottleneck of the existing industrial assembly type concrete building structure application development can be broken.
Owner:浙江省建筑科学设计研究院有限公司

Power tube gate driving circuit and sectional driving method

The invention provides a power tube gate driving circuit and a sectional driving method. The power tube gate driving circuit comprises a pre-driving stage, an output voltage comparison unit and a tri-state compensation driving stage, wherein the pre-driving stage is used for controlling rising time and falling time of a driving signal, so as to switching on or off an insulated gate power switching device; the output voltage comparison unit is used for comparing voltage of the driving signal output by the pre-driving stage with a set threshold value, and then outputting a switching control signal; and the tri-state compensation driving stage is used for charging or discharging a driving output port in a compensatory manner under the enabling action of a switching control signal and the action of the switching control signal output by the output voltage comparison unit, and accelerating the driving output port to pull up or pull down, so as to fully switching on or off the insulated gate power switching device. The power tube gate driving circuit is simple in structure, requires no resistance and capacitance devices, reduces domain area, and has the advantages that gate charging / discharging speed is less affected by variation of capacitive loads, the efficiency is high, the driving circuit is safe and reliable, and the like. The sectional driving method can reduce EMI effectively and reliably.
Owner:CRM ICBG (WUXI) CO LTD
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