The invention discloses a multifunctional rehabilitation exercise device for serious illness of neurosurgery. The multifunctional rehabilitation exercise device comprises a bottom plate, a first supporting plate, a second supporting plate, a third supporting plate, a motor, a first lead screw, a first nut, a first ejector rob, a connection sleeve, a second lead screw, a second nut, a second ejector rob, a rope wheel, a rope belt, a first spring, vibrators, massage balls, moxibustion boxes, heating wires, a temperature controller, a guide groove, pulleys, a first motor, a first rotating plate, a glove, a fixing plate, a second motor, a second rotating plate and a foot strap. The multifunctional rehabilitation exercise device for serious illness of neurosurgery is ingenious in structure, powerful in function and simple in operation, a patient just needs to lie on a hospital bed to achieve exercise treatment of the hands, , the feet, the upper body and the lower body of the patient, medical disputes generated by tumble and other accidents occurring when the patient is transferred to a specified exercise place are avoided, the rehabilitation progress of the patient is greatly accelerated, work efficiency of medical staff is greatly improved, labor intensity of medical staff is lowered, and the multifunctional rehabilitation exercise device can be used for various types of hospital beds in a universal mode.