The invention discloses an optical coating and transfer printing combined surface treatment method. The method comprises the steps that glass is subjected to rough shape cutting; the glass is subjected to CNC carving machining to obtain the needed 2.5 D cambered surface, tapped holes and chamfers; the glass is subjected to polishing treatment; the glass is subjected to hardening treatment; a PET membrane with an OCA adhesive is subjected to silk-screen printing treatment; the PET membrane is subjected to UV embossing treatment; the PET membrane is subjected to optical coating treatment; the PET membrane is subjected to silk-screen printing treatment; the treated glass and the treated PET membrane are subjected to laminating treatment, a semi-finished product is formed, the semi-finished product is subjected to anti-fingerprint coating, and the finished product is obtained. According to the optical coating and transfer printing combined surface treatment method, secondary machining is conducted on the periphery of the glass, certain radian is formed, ergonomics is better met, and a more comfortable touch feeling is achieved; by conducting surface treatments such as optical coating and texture transfer printing on the 2.5 D glass, the 2.5 D glass has a richer and more changeable visual effect, and the appearance competitiveness of the product is greatly promoted.