115results about How to "More effective" patented technology

Described is a prosthetic valve assembly comprising: a radially self-expandable stent configured to expand to bear against a wall of a native body lumen; and an implantable prosthetic valve, having a diameter, the valve being mounted inside the stent; wherein the diameter of the stent is greater than the diameter of the prosthetic valve.

Described is a prosthetic valve assembly comprising: a radially self-expandable stent configured to expand to bear against a wall of a native body lumen; and an implantable prosthetic valve, having a diameter, the valve being mounted inside the stent; wherein the diameter of the stent is greater than the diameter of the prosthetic valve.

A curcumin analog in which natural curcumin is modified by an amino acid moiety that increases the analog's transport across the blood brain barrier by the LAT1 transporter.

A system and method for providing digital audio services is described. One embodiment is a method for proving digital audio services, comprising receiving, using a communications interface, an audio stream from a content provider; determining a timestamp for a first audio stream segment; determining a timestamp for a second audio stream segment; updating playlist with a representation of the audio stream; receiving query for content information; and sending offer information, in response to receiving the query for content information.

The present invention relates to intranasally administering a pharmaceutical composition comprising curcumin to an upper third of a nasal cavity of the mammal, wherein the curcumin is absorbed through a nasal mucosa and transported to the brain of the mammal.

The invention relates to a method for handwriting detection using a handwriting tool (2) being arranged for communicating with a further device (2) and comprising the following steps: recognizing characters using detection of movements carried out by means of said handwriting tool (2); determining the probability factor of at least one input character corresponding to a given character; and using said probability factor in a step for correction, completion and prediction of words being formed by said characters. The invention also relates to a device for such handwriting detection.

A system and methods to integrate, secure and simplify transaction conducted by means of a mobile electronic communications device such as a cell phone or smartphone, combining biometric identification, computer software applications resident in the device's memory, PAN (personal area network) and data storage and transmission means, such system and methods being useful in credit or debit card transactions, automated transmission and retrieval of private medical information and the retrieval of law enforcement data, among other possible uses, purposes and applications.

This invention relates to novel fusion proteins which are comprised of a targeting protein that binds tissue factor (TF), which is operably linked to the thrombomodulin (TM) EGF456 domain alone or in combination with at least one other TM domain selected from the group consisting of the N-terminal hydrophobic region domain, the EGF123 domain, the interdomain loop between EGF3 and EGF4, and the O-glycosylated Ser / Thr-rich domain, or analogs, fragments, derivatives or variants thereof. The fusion protein binds at the site of injury and prevents the initiation of thrombosis. The fusion protein can be used to treat a variety of thrombotic conditions including but not limited to deep vein thrombosis, disseminated intravascular coagulation, and acute coronary syndrome.

Intranasally administering curcumin prodrugs and curcumin analog prodrugs to the brain to treat Alzheimer's Disease

The present invention is directed to a compound represented by Structural Formula (I):or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I) and its therapeutic use.

Polymer-based selective radiative cooling structures are provided which include a selectively emissive layer of a polymer or a polymer matrix composite material. Exemplary selective radiative cooling structures are in the form of a sheet, film or coating. Also provided are methods for removing heat from a body by selective thermal radiation using polymer-based selective radiative cooling structures.

This invention relates to novel fusion proteins which are comprised of a targeting protein that binds tissue factor (TF), which is operably linked to the thrombomodulin (TM) EGF456 domain alone or in combination with at least one other TM domain selected from the group consisting of the N-terminal hydrophobic region domain, the EGF123 domain, the interdomain loop between EGF3 and EGF4, and the O-glycosylated Ser / Thr-rich domain, or analogs, fragments, derivatives or variants thereof. The fusion protein binds at the site of injury and prevents the initiation of thrombosis. The fusion protein can be used to treat a variety of thrombotic conditions including but not limited to deep vein thrombosis, disseminated intravascular coagulation, and acute coronary syndrome.

This invention relates to novel fusion proteins which are comprised of a targeting protein that binds tissue factor (TF), which is operably linked to the thrombomodulin (TM) EGF456 domain alone or in combination with at least one other TM domain selected from the group consisting of the N-terminal hydrophobic region domain, the EGF123 domain, the interdomain loop between EGF3 and EGF4, and the O-glycosylated Ser / Thr-rich domain, or analogs, fragments, derivatives or variants thereof. The fusion protein binds at the site of injury and prevents the initiation of thrombosis. The fusion protein can be used to treat a variety of thrombotic conditions including but not limited to deep vein thrombosis, disseminated intravascular coagulation, and acute coronary syndrome.

A highly specific and easily purified form of hyaluronidase is described for use in ophthalmic treatments. The enzyme, from Streptomyces hyalurolyticus is specific for hyaluronidase and carries out an elimination reaction that results in the production of double bonds at the nonreducing end of hyaluronic acid. Hyaluronidase from Streptomyces hyalurolyticus has a higher activity than comparable enzymes from other species. The enzyme is now capable of being purified in what is essentially a protease-free form making it applicable to medical treatments. The use of this source of hyaluronidase in ophthalmic treatments is now made possible by its high activity, specificity for hyaluronidase and purity.

The invention features methods and compositions for diagnosis and treatment of conditions associated with decreased nitric oxide bioavailability, such as a condition associated with elevated arginase activity, using an arginine- and / or arginase-inhibitor based therapy, which therapies include administration of arginine or an arginase inhibitor, either alone or in combination. The invention also contemplates administration of magnesium with arginine, an arginase inhibitor, or with arginine-arginase inhibitor combination therapy. The invention also features methods and compositions for diagnosis, including prognosis, of conditions associated with arginase activity by assessing the ratio of arginine to ornithine in samples from a subject.

Novel molecules based upon hybridization of curcumin and hydroxystilbenes, such as resveratrol. It is believed that these novel molecules will have special application in treating Alzheimer's Disease.

Flame retardant compositions, and compositions that comprise an organic polymer and the flame retardant composition are disclosed. The flame retardant compositions are prepared by reacting ethylene diamine with polyphosphoric acid; or reacting an ethyleneamnine or a mixture of ethyleneamines with phosphoric acid, polyphosphoric acid, pyrophosphoric acid, or mixtures thereof. A 10% by weight solution of the product in water has a pH between about 2.5 to 6.0. The flame retardant compositions are non-halogen containing flame retardant compositions and do not gas undesirably during processing at temperatures of 235° C. or even higher.

The present invention relates to an arthroscopy apparatus, comprising at least three elements selected from: a conventional arthroscopic lens (12), to which there is coupled a power supply device or capsule, in the inside of which is the power source (1), and a miniature camera (8), characterized by not comprising connecting cables.

A methylene blue—curcumin hybrid useful in treating Alzheimer's Disease.

Intranasally administering curcumin prodrugs and curcumin hybrids in a bolus of helium gas to the brain to treat Alzheimer's Disease

The present invention relates to a process for obtaining fatty acid esters from triglycerides by means of alcoholysis. In particular, the invention relates to a process for the transesterification of fat and / or oil by alcoholysis wherein, in order to accelerate the process in the initial stage, at least one alkanol fatty acid ester is added in a quantity such that the reaction mixture produced thereby consists of one phase. A high reaction rate can thereby be maintained in the process from the beginning.

This invention relates to a high-strength herbicidal formulation containing high concentrations of glyphosate monomethylamine or dimethylamine salt and one or more surfactants selected to enhance the herbicidal activity of the glyphosate salts. The formulations exhibit significantly lower viscosity at high concentrations.

A system and method for automatically constructing personalized video clips for a viewer.

This invention discloses a lithium metal oxide powder for a cathode material in a rechargeable battery, consisting of a core and a surface layer, the core having a layered crystal structure comprising the elements Li, M and oxygen, wherein M has the formula M=(Niz(Ni1 / 2Mn1 / 2)yCox)1-kAk, with 0.15≦x≦0.30, 0.20≦z≦0.55, x+y+z=1 and 0≦k≦0.1, wherein A is a dopant, wherein the Li content is stoichiometrically controlled with a molar ratio 0.95≦Li:M≦1.10; and wherein the surface layer comprises the elements Li, M′ and oxygen, wherein M′ has the formula M′=(Niz′(Ni1 / 2Mn1 / 2)y′Cox′)1-k′Ak′, with x′+y′+z′=1 and 0≦k′≦0.1, and wherein y′ / (y′+2z′)≧1.1*[y / (y+2z)]. The surface layer may also comprise at least 3 mol % Al, the Al content in the surface layer 10 being determined by XPS.

A method for recovering blood from a blood-laden surgical sponge for autologous reinfusion, the method comprising the steps of: conveying negative pressure to a housing with the blood-laden surgical sponge; applying a predetermined force to draw the blood from the surgical sponge; and collecting the recovered blood.

A buoyant walkway or island and its method of manufacture. In a preferred embodiment, the buoyant walkway comprising: an internal frame comprising semi-rigid members that are attached to one another, said internal semi-rigid frame having openings; an internal block disposed in each of said openings, said internal blocks being spaced apart from one another by gaps and forming a top surface and a bottom surface; cured thermoplastic foam disposed in said gaps that attach said internal blocks to said semi-rigid internal frame and to one another; a permeable top layer that is attached to said top surface; and a bottom layer that is attached to said bottom surface.

A method and an apparatus for extracting signals which are indicative of the level of consciousness of a patient comprises subjecting the patient to a repetitive audio stimulus, monitoring AEP produced by the patient using an autoregressive model with exogenous input, and then calculating an index (AAI), which is displayed or used otherwise,indicative of the anaesthetic depth.

The invention provides a remote monitoring system which has a simplified configuration and is capable of remotely monitoring the current state of a person needing care and detecting an abnormality in the person's behavior and then addressing the abnormality, and further provides a method using the remote monitoring system. The remote monitoring system comprises: a communication line 3 for sending information indicating occurrence of an abnormality from a security device 1 to a terminal device 2 via an email support line and a telephone line; a central processing unit 11 for detecting that a user at said terminal device does not acquire the information indicating occurrence of an abnormality until a first predetermined time period has passed since the security device began sending the information indicating occurrence of an abnormality and sending out a first detection signal, and for detecting that the user at said terminal device does not acquire the information indicating occurrence of an abnormality until a second predetermined time period has passed since expiration of said first predetermined time period and sending out a second detection signal; detection means consisting of a detection circuit 16, etc.; control means consisting of the central processing unit 11 and a communication control unit 15, etc., and provided for allowing the communication line 3 to provide the email support line until the first predetermined time period has passed since the information indicating occurrence of an abnormality began to be sent and to provide the telephone line in response to the first detection signal; and an alarm generation unit 17, provided in the security device 1, for generating a first alarm in response to the first detection signal and generating a second alarm, which rings louder than the first alarm does, in response to the second detection signal.

The invention provides a remote monitoring system which has a simplified configuration and is capable of remotely monitoring the current state of a person needing care and detecting an abnormality in the person's behavior and then addressing the abnormality, and further provides a method using the remote monitoring system. The remote monitoring system comprises: a communication line 3 for sending information indicating occurrence of an abnormality from a security device 1 to a terminal device 2 via an email support line and a telephone line; a central processing unit 11 for detecting that a user at said terminal device does not acquire the information indicating occurrence of an abnormality until a first predetermined time period has passed since the security device began sending the information indicating occurrence of an abnormality and sending out a first detection signal, and for detecting that the user at said terminal device does not acquire the information indicating occurrence of an abnormality until a second predetermined time period has passed since expiration of said first predetermined time period and sending out a second detection signal; detection means consisting of a detection circuit 16, etc.; control means consisting of the central processing unit 11 and a communication control unit 15, etc., and provided for allowing the communication line 3 to provide the email support line until the first predetermined time period has passed since the information indicating occurrence of an abnormality began to be sent and to provide the telephone line in response to the first detection signal; and an alarm generation unit 17, provided in the security device 1, for generating a first alarm in response to the first detection signal and generating a second alarm, which rings louder than the first alarm does, in response to the second detection signal.

A tap dance shoe system and method involving a tap shoe (1), including a sole (10), having at least one sole layer (6) and a toe portion (4), and a heel (5), having at least one heel layer (6) and a heel portion (7); a toe insert (8) disposed at the toe portion (4); a heel insert (9) disposed at the heel portion (7); a toe tap (10) disposed at the toe portion (4); a heel tap (11) disposed at the heel portion (7); a structure (12) for mounting together the inserts (8, 9) and the corresponding portions (4, 7); and a structure (13) for adjustably coupling the taps (10, 11) and the corresponding inserts (8, 9).