The invention provides an intelligent packing box capable of being quickly sealed and opened. The intelligent packing box includes a box body, and a box cover integrated with the box body, a box opening is formed in the box body, the box cover comprises a left enclosed lacing, a right enclosed lacing, a lower rocker cover plate and an upper rocker cover plate, wherein the left enclosed lacing, theright enclosed lacing, the lower rocker cover plate and the upper rocker cover plate are connected with the box body, a first coated sealing edge is arranged at the edge, close to the box body, of the lower rocker cover plate, and a second coated sealing edge is arranged at the edge, away from the box body, of the lower rocker cover plate; and during splicing, the left enclosed lacing and the right enclosed lacing cover the box opening, the lower rocker cover plate covers the left enclosed lacing and the right enclosed lacing, the upper rocker cover plate covers the lower rocker cover plate,and the lower rocker cover plate and the upper rocker cover plate are bonded and fixed through the first coated sealing edge and the second coated sealing edge. By means of the intelligent packing boxcapable of being quickly sealed and opened, the box cover can realize the quick sealing and opening, and the functions of anti-counterfeiting and information reading can be achieved by additionally arranging an intelligent label.