The invention relates to a method for determining the anisotropic elastic modulus of a schist, and aims at providing the method for determining the anisotropic elastic modulus of the schist so as to provides a reliable foundation for accurately estimating the stability of a tunnel of the deeply burned schist and late support. The technical scheme disclosed by the invention is that the method for determining the anisotropic elastic modulus of the schist is characterized by comprising the following steps of: a, carrying out scene nondestructive sampling; b, obtaining three groups of rock cores drilling in parallel direction, in vertical direction and in a direction in which boreholes and the schist form certain included angles; c, respectively carrying out a uniaxial compression test on the three groups of rock cores, so as to obtain an intact stress-strain curve of each rock core, and obtain the mean elastic modulus and the mean poisson ratio of each group of rock cores; d, inserting the test result obtained from the step c into the following formula to determine variable G'; and e, inserting E, E', v' and G' into the formula, and then taking the inverse number, so as to obtain a curve of which the elastic modulus of the loading direction changes along the included angles beta. The method is suitable for deeply buried tunnel engineering.