The invention provides a method for adjusting the variable flow line vector of thick-bed oil reservoirs. The method for adjusting the variable flow line vector of thick-bed oil reservoirs includes: step 1, conducting reservoir heterogeneity research; step 2, establishing a numerical simulation model, and Carry out history matching; step 3, conduct research on the distribution of remaining oil saturation; step 4, carry out the design of the well pattern variable flowline adjustment scheme; step 5, use numerical simulation technology to predict the ultimate recovery of the variable flowline scheme, according to Then optimize the variable streamline scheme; step 6, optimize the water injection parameter vector, and use numerical simulation technology to predict the final recovery factor of the vector water injection parameter optimization scheme. The variable streamline vector adjustment method for thick-bed reservoirs is highly practical, and can effectively slow down the production decline and water-cut rise of thick-bed reservoirs during the ultra-high water cut period, and improve the water flooding development effect.