The invention relates to the technical field of digital printing T-shirts, and discloses a preparation process of a ventilated and breathable digital printing T-shirt, which is characterized by comprising the following steps: preparing raw materials: preparing 120-150g of cotton fiber, 10-20g of spandex fiber, 20-40g of polyester fiber and 10-20g of viscose acetal fiber, preparing the T-shirt: preparing 120-150g of cotton fiber, 10-20g of spandex fiber, 20-40g of polyester fiber and 10-20g of viscose acetal fiber, and preparing the T-shirt by uniformly mixing the raw materials with the cotton fiber, the spandex fiber, the polyester fiber and the viscose acetal fiber; 20-40 g of polyester fibers and 10-20 g of viscose fibers are made into the T-shirt through a conventional technology, and pattern selection is conducted, specifically, a webpage is browsed on a computer, a pattern which finally needs to be printed is selected, then the pattern is edited, and the final pattern is made. According to the preparation process of the ventilated and breathable digital printing T-shirt, by arranging the air purification device, peculiar smell generated during ink jetting can be filtered and purified, in this way, the process has the peculiar smell removal function, the generated peculiar smell can be adsorbed and filtered when ink jetting is conducted on the T-shirt, the air quality of a workshop is improved, and the production cost is reduced. And the damage to the body health of workers is reduced.