The invention discloses a method for realizing secure access of data in a hard disk. The method is realized by the following steps: establishing a secure space on the hard disk and monitoring the secure space; automatically encrypting the data written in the secure space; associating the secure space with a USBKEY; and setting protection passwords required for opening the secure space. When the data in the secure space is accessed, USBKEY authentication and passwords authentication are carried out in sequence, the secure space can be opened only after the double authentication; and when the situation that the data in the secure space is accessed but the secure space is not opened is monitored, whether the USBKEY authentication passes or not is checked, if not, the accessing is blocked, and a preset ISMG (internet short message gateway) or/and an instant communication port is/are used for sending an alarm information to a user. In the invention, by virtue of the double authentication and the monitoring on the secure space, the secret-divulging risk is reduced, the effects of safety, rapidness and easiness in use are achieved, and the active defense and active alarming are also realized, therefore, the safety is improved to the maximum extent.