The invention discloses a wheeze sound multi-channel detection airway excitation tester and a method for picking up and applying the wheeze sound, comprising a drug atomization device, several pickups for picking up the wheeze sound, and a device for collecting the wheeze sound A controller for amplification processing, analog-to-digital conversion, synchronous conversion, and calculation processing of signals input by the pickup and electrode patches, and an output device, which is electrically connected to the controller for image display, audio playback, and electronic medical record printout. Since the pickup is set, the wheezing sound can be collected, and the wheezing sound can be picked up; because the controller, memory and output device are set, the collected signal is processed by the controller, and the generation of the wheezing sound is judged and analyzed. , and synchronize the wheezing sound with the respiratory waveform, the storage of the wheezing sound can be realized through the memory, and the playback, restoration, real-time recording, marking and printing of the wheezing sound can be realized through the output device due to the setting of the output device.