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85 results about "Analysis dna" patented technology
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DNA analysis is the process in which genetic sequences are studied. It is used by law enforcement and medical personnel to identify a particular person or species, and even specific cancers and diseases.
Methods and compositions for flow cytometric determination of DNA sequences
InactiveUS6057107AReduce fluorescenceReduce intensityMicrobiological testing/measurementIndividual particle analysisAnalysis dnaTest sample
A method for the analysis of DNA sequences and PCR products comprises the steps of constructing an oligonucleotide-labeled beadset, and labeled complementary probe, and exposing the beadset and probe to a DNA fragment or PCR product under hybridizing conditions and analyzing the combined sample / beadset by flow cytometry. Flow cytometric measurements are used to classify beads within an exposed beadset to determine the presence of identical or nonidentical sequences within the test sample. The inventive technology enables the rapid analysis of DNA sequences and detection of point mutations, deletions and / or inversions while also reducing the cost and time for performing genetic assays.
Owner:LUMINEX
Method of analyzing DNA sequence using field-effect device, and base sequence analyzer
ActiveUS7888013B2Bioreactor/fermenter combinationsHeating or cooling apparatusAnalysis dnaFluorescence
Owner:NAT INST FOR MATERIALS SCI
Method of Analyzing Dna Sequence Using Field-Effect Device, and Base Sequence Analyzer
ActiveUS20080286767A1Bioreactor/fermenter combinationsHeating or cooling apparatusAnalysis dnaFluorescence
Since conventional DNA sequence analyzing technologies are based on the fundamental principle of fluorescent detection, expensive, complex optical systems and laser sources have been necessary.A field-effect device for gene detection of the present invention analyzes a base sequence by immobilizing a single-strand nucleic acid probe at a gate portion, inducing hybridization at the gate portion to form a double-stranded DNA, inducing elongation reaction by adding a DNA polymerase and one of the substrates, and measuring the electrical characteristic of the field-effect device caused by elongation reaction.Since the elongation reaction of one base induced at the gate portion can be directly converted to an electrical signal, expensive lasers or complex optical systems are not needed. Thus, a small gene polymorphism detection system that can conduct measurement at high precision can be provided.
Owner:NAT INST FOR MATERIALS SCI
Reagents for reversibly terminating primer extension
Processes are disclosed that use 3′-reversibly terminated nucleoside triphosphates to analyze DNA for purposes other than sequencing using cyclic reversible termination. These processes are based on the unexpected ability of terminal transferase to accept these triphosphates as substrates, the unexpected ability of polymerases to add reversibly and irreversibly terminated triphosphates in competition with each other, the development of cleavage conditions to remove the terminating group rapidly, in high yield, and without substantial damage to the terminated oligonucleotide product, and the ability of reversibly terminated primer extension products to capture groups. The presently preferred embodiments of the disclosed processes use a triphosphate having its 3′-OH group blocked as a 3′-ONH2 group, which can be removed in buffered NaNO2 and use variants of Taq DNA polymerase, including one that has a replacement (L616A).
Owner:BENNER STEVEN ALBERT +3
Mobile Biometrics Information Collection and Identification
ActiveUS20120148115A1Minimal costCosts of hardware modifications and associated software requirementsDigital data authenticationProteomicsHuman bodyPattern recognition
A biometric mobile device is capable of interacting with existing cellular, wireless, and wired telecommunication and other communication networks to support intelligence gathering, human body identification, special operations and other applications. A method of collecting biometric data at an accident or crime scene may comprise, for example, utilizing a camera to photograph the accident scene, collecting key entered data that may not be otherwise obtainable, using a fingerprint scanner to collect, digitize and store fingerprint data, using a lab-on-a-chip DNA profile device for collecting and analyzing a DNA specimen and generating identification and DNA profile data for bar code entry and other means for collecting any known form of biometric data including, but not limited to, vascular facial structure, dental structure, cornea, iris or other data which may be unique or limiting for identification purposes.
Owner:BIRDWELL J DOUGLAS +2
Frozen tissue microarray technology for analysis RNA, DNA, and proteins
InactiveUS6893837B2Withdrawing sample devicesPreparing sample for investigationAnalysis dnaTissue Arrays
The invention disclosed herein improves upon existing tissue microarray technology by using frozen tissues embedded in tissue embedding compound as donor samples and arraying the specimens into a recipient block comprising tissue embedding compound. Tissue is not fixed prior to embedding, and sections from the array are evaluated without fixation or post-fixed according to the appropriate methodology used to analyze a specific gene at the DNA, RNA, and / or protein levels. Unlike paraffin tissue arrays which can be problematic for immunohistochemistry and for RNA in situ hybridization analyses, the disclosed methods allow optimal evaluation by each technique and uniform fixation across the array panel. The disclosed arrays work well for DNA, RNA, and protein analyses, and have significant qualitative and quantitative advantages over existing methods.
Owner:RGT UNIV OF CALIFORNIA
Method for obtaining human skin DNA samples with an adhesive sheet
Provided is a method for obtaining human DNA for genetic analysis, by taking the epidermis of testee by means of an adhesive sheet, and by extracting DNA from the epidermis stuck on the adhesive sheet. Provided are also combined sheets for conveniently storing DNA and a kit for taking the epidermis and analyzing DNA. Along with the kits, the method allows DNA to be easily obtained and stably stored for a long period of time. In addition, both the identification and the DNA analysis of a testee can be conducted at the same time by taking epidermal scraps from the testee, along with a figured epidermal print.
Owner:SPECIALTY LAB SOLUTION BIO CO LTD
Use of representations of DNA for genetic analysis
InactiveUS20050266444A1Simplify complexityEfficient removalBioreactor/fermenter combinationsBiological substance pretreatmentsAnalysis dnaGenetic analysis
It is an object of the present invention to provide a solution to problems associated with the use of microarray technology for the analysis DNA. The present invention provides compositions and methods for the use of simple and compound representations of DNA in microarray technology. The present invention is also directed to methods for the production of High Complexity Representations (HCRs) of the DNA from cells.
Owner:COLD SPRING HARBOR LAB INC
Use of representations of DNA for genetic analysis
InactiveUS20050196799A1Simplify complexityEfficient removalBioreactor/fermenter combinationsBiological substance pretreatmentsAnalysis dnaGenetic analysis
It is an object of the present invention to provide a solution to problems associated with the use of microarray technology for the analysis DNA. The present invention provides compositions and methods for the use of simple and compound representations of DNA in microarray technology. The present invention is also directed to methods for the production of High Complexity Representations (HCRs) of the DNA from cells.
Owner:COLD SPRING HARBOR LAB INC
Method for measuring chromosome, gene or specific nucleotide sequence copy numbers using SNP array
InactiveUS9012370B2Easy to deleteReadily duplicationMicrobiological testing/measurementLibrary screeningAnalysis dnaTest sample
Owner:NAT CANCER CENT
Microfluidic device for extracting, isolating, and analyzing DNA from cells
ActiveUS20140194313A1Facilitates single-molecule analysisReducing background fluorescenceVolume/mass flow measurementLibrary screeningAnalysis dnaCell separation
Owner:CORNELL UNIVERSITY
Method and apparatus for allele peak fitting and attribute extraction from DNA sample data
InactiveUS20090228245A1Low costComponent separationComputation using non-denominational number representationAnalysis dnaAllele
Analysis of DNA is critical to many applications including identifying perpetrators of crimes based on genetic evidence left at crime scenes. An initial step to analyzing DNA data is detection, identification, and quantization of allele peaks in the DNA data. The invention provides a method and apparatus for accurately and expeditiously performing this initial step by sequentially checking unfitted peaks against various models including a default model, a hybrid peak model, a dual fit model and, in special situations, a narrow fit function and a saturated fit function.
Owner:UNIV OF TENNESSEE RES FOUND
Method for the mapping of the local at/gc ratio along DNA
ActiveUS20110201509A1Low costIncrease speedHeating or cooling apparatusMicrobiological testing/measurementAnalysis dnaBioinformatics
Owner:TEGENFELDT JONAS +2
Use of reflections of DNA for genetic analysis
InactiveUS20030049663A1Sugar derivativesMicrobiological testing/measurementAnalysis dnaGenetic analysis
The present invention to provides a solution to problems associated with the use of hybridization for genetic analysis, including but not limited to the use of microarray technology for the analysis DNA. The present invention provides compositions and methods for the use reflections of DNA in genetic analysis. The present invention is also directed to methods for the production of reflections of DNA.
Owner:COLD SPRING HARBOR LAB INC
Method and apparatus for encoding cellular spatial position information
A system, methods, and apparatus are described to collect and prepare single cells and groups of cells from microsamples of specimens and encode spatial information of the physical position of the cells in the specimen. In some embodiment, beads or surfaces with oligonucleotides containing spatial barcodes are used to analyze DNA or RNA. The spatial barcodes allow the position of the cell to be defined and the nucleic acid sequencing information, such as target sequencing, whole genome, gene expression, used to analyze the cells in a microsample for cell type, expression pattern, DNA sequence, and other information, in the context of the cell's physical position in the specimen. In other embodiment, markers such as isotopes are added to a microsample to encode spatial position with mass spectoscopy or other analysis. The spatial encoded information is then readout by analysis such as DNA sequencing, mass spectrometry, fluorescence, or other methods.
Owner:SILICON VALLEY SCI
Compound amplification kit of 20 short tandem repeats
The invention relates to a compound amplification system for simultaneously analyzing a plurality of STR (short tandem repeat) loca, which is characterized by being used for carrying out compound amplification on 20 locas: Amelogenin, vWA, D21S11, D18S51, D5S818, D7S820, D13S317, D16S539, FGA, D2S1338, D19S433, D6S1043, D12S391, D8S1179, D3S1358, CSF1PO, Penta D, Penta E, TH01 and TPOX. The invention also relates to a method and a kit for simultaneously analyzing DNA (deoxyribonucleic acid) samples and other applications of the loca.
Owner:BEIJING PEOPLESPOT TECH +1
Composite amplification kit for 26 Y chromosome short tandem repeats
ActiveCN104017895AHigh individual recognition rateImprove compatibilityMicrobiological testing/measurementDNA/RNA fragmentationAnalysis dnaTandem repeat
The invention relates to a composite amplification system for simultaneously analyzing multiple Y-STR loci. The composite amplification kit is characterized by compositely amplifying the following 26 Y chromosome loci: DYS19, DYS388, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385a, DYS385b, DYS437, DYS438, DYS439, DYS448, DYS456, DYS458, DYS635, DYS460, DYS481, DYS533, DYS549, DYS570, DYS576, DYS643, DYS449 and Y-GATA-H4. The invention also relates to a method and a kit for simultaneously analyzing DNA samples, and applications thereof.
Owner:BEIJING PEOPLESPOT TECH
Methods and arrays for profiling DNA methylation
This invention provides methods and arrays for determination of the methylation patterns at single-nucleotide resolution by array-based hybrid selection and next-generation sequencing of bisulfite-treated DNA.
Owner:COLD SPRING HARBOR LAB INC
Detection of DNA hydroxymethylation
Reagents and methods for analysis of DNA hydroxymethylation are provided. Methods comprise modification of hydroxymethylated cytosine residues with a bulky moiety to protect hydroxymethylated positions from cleavage with a DNA endonuclease. For example, methods may comprise contacting DNA with a glucosyltransferase to glucosylate hydroxymethylated DNA positions and digesting the DNA with a DNA endonuclease to cleave DNA in positions lacking hydroxymethylation. Reagents and kits for hydroxymethylated DNA analysis are also provided.
Owner:ZYMO RES CORP
Projectile blood collection device
This disclosure describes a device for obtaining a blood sample from an intruder at a crime scene to be later analyzed for DNA. A projectile containing a blood-extracting needle for penetrating the skin of said intruder is mounted through a protective chamber and connected to a blood reservoir in the chamber interior. A vacuum is held in both the reservoir and the chamber. The chamber vacuum is released by forward movement of the chamber as it slides within a casing following further penetration of the needle. The vacuum release acts to reduce the ambient pressure within the forward portion of the casing, thus assisting in propelling the needle into the intruder. As the needle reaches maximum extension, a loaded spring within the casing is released, propelling the needle and reservoir away from the intruder.
Owner:MCNENNY JAMES H
Mobile biometrics information collection and identification
ActiveUS9235733B2Costs of hardware modifications and associated software requirementsMinimal costDigital data authenticationProteomicsHuman bodyPattern recognition
A biometric mobile device is capable of interacting with existing cellular, wireless, and wired telecommunication and other communication networks to support intelligence gathering, human body identification, special operations and other applications. A method of collecting biometric data at an accident or crime scene may comprise, for example, utilizing a camera to photograph the accident scene, collecting key entered data that may not be otherwise obtainable, using a fingerprint scanner to collect, digitize and store fingerprint data, using a lab-on-a-chip DNA profile device for collecting and analyzing a DNA specimen and generating identification and DNA profile data for bar code entry and other means for collecting any known form of biometric data including, but not limited to, vascular facial structure, dental structure, cornea, iris or other data which may be unique or limiting for identification purposes.
Owner:BIRDWELL J DOUGLAS +2
System and method for analyzing DNA using application of mobile device
InactiveUS20140287414A1Bioreactor/fermenter combinationsHeating or cooling apparatusSmall sampleAnalysis dna
A DNA analysis system that controls DNA analysis by wireless using an application of a mobile device and a very small DNA analysis apparatus, and that receives a DNA analysis result in real time on the spot is provided. Therefore, by performing DNA analysis by simultaneously controlling a plurality of small DNA analysis apparatuses using signal processing and screen display functions of a mobile device, analysis speed of DNA is improved, and an analysis result of DNA can be provided in real time. Further, by forming a DNA analysis apparatus in a very small size, DNA can be immediately analyzed with low power consumption on the spot using a small sample, and the DNA analysis apparatus can be carried.
Owner:ELECTRONICS & TELECOMM RES INST
Analysis of methylation using selective adaptor ligation
InactiveUS20080254453A1Reduce complexityMicrobiological testing/measurementFermentationCytosineAnalysis dna
Methods of analyzing DNA to identify regions of the genome that are methylated in a genomic sample are disclosed. In one aspect genomic DNA is fragmented using a restriction enzyme with a degenerate recognition site, methylated restriction fragments are separated from unmethylated fragments by affinity purification. The complexity of the methylated fragments is reduced by amplification of a subset of the fragments using adaptors that ligate to a subset of the fragments. The amplified product is fragmented, labeled and hybridized to an array of probes. The hybridization pattern is analyzed to determine methylation status of cytosines.
Owner:AFFYMETRIX INC
Quantitation of cellular DNA and cell numbers using element labeling
ActiveUS20080193930A1Microbiological testing/measurementCharacter and pattern recognitionAnalysis dnaElemental analysis
Methods and kits for the quantitation of cellular DNA and cell numbers are provided. Passive element uptake, element-labeled DNA intercalators, and element labeled affinity reagents are used to quantify DNA and cells. The DNA and the cells are analyzed by elemental analysis, including ICP-MS. The methods and kits provide a fast and accurate analysis of cellular DNA and cell numbers.
Owner:STANDARD BIOTOOLS CANADA INC
Method of detecting error spot in DNA chip and system using the method
InactiveUS20050186670A1Improve reliabilityBioreactor/fermenter combinationsBiological substance pretreatmentsAnalysis dnaStatistical analysis
Provided are a method of detecting an error spot and a system using the method. The method includes analyzing a difference in variances of a background intensity and a foreground intensity for each spot in a DNA chip, verifying whether the mean of the background intensity and the mean of the foreground intensity are significantly different from each other based on the difference in variances, and judging an error spot based on the results of the verifying operation. Thus, the reliability in statistical analysis can be increased by excluding the error spot in the statistical analysis.
Owner:SAMSUNG ELECTRONICS CO LTD
Method for determining base sequence of DNA
InactiveUS20100009354A1Fast sequencingBioreactor/fermenter combinationsBiological substance pretreatmentsAnalysis dnaFluorescence
The present invention provides a method for determining the base sequence of a DNA. According to the method for determining the base sequence of a DNA of the present invention, a probe is used, which is a probe having a protruding end and identification-labeled according to the species of the base at the protruding end, containing a recognition sequence of a class IIS restriction enzyme, to carry out simultaneously in a chain reaction, for a plurality of DNAs to be analyzed, ligation of the end base of a DNA to be analyzed and a probe and cleavage of the end base of the DNA to be analyzed, allowing the base sequence to be determined sequentially by a single molecule spectrofluorimetry method, such that an effective determination of the base sequence of a DNA becomes possible.
Owner:NAT UNIV HOKKAIDO UNIV 10 +1
Apparatus and method for analyzing state of DNA
InactiveUS20130130237A1Bioreactor/fermenter combinationsBiological substance pretreatmentsAnalysis dnaIrradiation
The present invention provides an analysis apparatus including: an irradiation section for irradiating the chromatin structure with terahertz waves; a detection section for acquiring a set of terahertz wave spectral information from the chromatin structure; a memory section for memorizing the sets of terahertz wave spectral information corresponding to the states of the chromatin structure; and a data processing section for analyzing the state of the chromatin structure by comparing the set of spectral information acquired in the detection section and the sets of spectral information memorized in the memory section.
Owner:CANON KK
Devices and processes for analyzing nucleic acid damage and repair using electrophoresis
ActiveUS20120277118A1Promote repairIncreased susceptibility to DNA damageLibrary screeningMaterial analysis by electric/magnetic meansAnalysis dnaElectrophoresis
Systems, methods, and devices are provided for assessing DNA damage and repair in cells by measuring DNA migration under electrophoresis. In one exemplary embodiment, a microarray configured to hold cells in a predetermined spatial relationship is employed to improve accuracy, speed, and reliability of such measurements. In another embodiment, a self-contained cassette having a matrix material disposed therein can be used to create a substantially uniform environment for analyzing DNA damage and repair. Fluid can be circulated through the cell to assist in creating spatial patterns on the matrix material, or alternatively, the matrix material can already include a microarray pattern disposed thereon. Various methods and systems that take advantage of such microarrays and cassettes are also provided.
Owner:MASSACHUSETTS INST OF TECH
Preservation of information related to genomic DNA methylation
The present invention relates to compositions, methods and systems for analyzing the methylation state of nucleic acids. Some embodiments relate to a compositions, methods and systems for analyzing the methylation state of DNA with a gene array.
Owner:ILLUMINA INC
Method and system for DNA analysis
The present invention pertains to a process for automatically analyzing nucleic acid samples. Specifically, the process comprises the steps of forming electrophoretic data of DNA samples with DNA ladders; comparing these data; transforming the coordinates of the DNA sample's data into DNA length coordinates; and analyzing the DNA sample in length coordinates. This analysis is useful for automating fragment analysis and quality assessment. The automation enables a business model based on usage, since it replaces (rather than assists) labor. This analysis also provides a mechanism whereby data generated on different instruments can be confidently compared. Genetic applications of this invention include gene discovery, genetic diagnosis, and drug discovery. Forensic applications include identifying people and their relatives, catching perpetrators, analyzing DNA mixtures, and exonerating innocent suspects.
Owner:PERLIN MARK W
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