The invention discloses a joint axis angle adjustable type multi-axis ankle joint prosthesis, and belongs to the technical field of bionic human prostheses. The joint axis angle adjustable type multi-axis ankle joint prosthesis is composed of a front part, a joint axis part, a left part, an upper cover, a rear part, a right part, a bottom cover and four springs, wherein the joint axis part is positioned in a space defined by the front part, the left part, the upper cover, the rear part, the right part and the bottom cover; the space angle of the joint axis below is adjusted by adjusting the positions of groove plates in the front part and the rear part; and the space angle of the ankle joint axis is adjusted by adjusting the positions of groove plates in the left part and the right part, and therefore the prosthesis can be attached to the human ankle joint structure to a larger extent. Different ankle joint axis angles can be adjusted for different wearers, and therefore the comfort degree of the wearers is improved, the movement coordination of the affected side limb and the normal side limb of the wearers is improved, the environment adaptability is improved, the joint axis angleadjustable type multi-axis ankle joint prosthesis can adapt to different road surface changes, and the energy consumption of the wearers is reduced.