The invention discloses a one-hand operation method of a large-screen touch screen mobile phone. The one-hand operation method comprises the following steps of: step 1, starting a program and starting a touch screen monitoring program; step 2, monitoring sliding operation of a user on a touch screen by a background; step 3, judging whether a thumbnail starting gesture is detected, if the thumbnail starting gesture is detected, carrying out a step 4, otherwise, returning to the step 2; step 4, generating a thumbnail through using a thumbnail generating algorithm; step 5, monitoring touch operation of the user on the thumbnail by the background; step 6, judging whether thumbnail operation is detected, if the thumbnail operation is detected, processing the thumbnail into a corresponding screen touch point by using a coordinate transformation algorithm, so as to enable the program to carry out corresponding screen operation, simultaneously update the display of the thumbnail, otherwise, carrying out a step 7; step 7, by the program, detecting whether closing operation is carried out on the thumbnail, if so, carrying out a step 8, otherwise, returning to the step 5; and step 8, closing the thumbnail, and ending the program. According to the one-hand operation method of the large-screen touch screen mobile phone, the touch control by one hand to the large-screen touch screen mobile phone is enhanced, and the user can enjoy the one-hand operation or the double-hand operation at any time, so that the user experience is obviously improved.