The invention discloses a pesticide spraying unmanned aerial vehicle with high safety, which comprises an unmanned aerial vehicle body, an inner cabin, a pesticide containing box, a protection box, aliquid outlet hose, an electric pipe cutter, a pesticide pumping pump, a pesticide spraying pipe, a quick striking device and a control device, wherein the inner cabin is arranged in the unmanned aerial vehicle body, a protection box is arranged in the inner cabin, a pesticide containing box is arranged in the protection box, a plurality of damping springs are arranged on the inner wall, top walland bottom wall of the protection box, the tail ends of the damping springs are fixed outside the pesticide containing box, one side of the inner cabin is provided with an electric opening and closingdoor which is communicated with the outside of the unmanned aerial vehicle body, one side of the inner cabin, away from the electric opening and closing door, is provided with the quick striking device, and the bottom of one side wall of the pesticide containing box is provided with the liquid outlet hose. According to the invention, the damping springs are arranged between the protection box andthe pesticide containing box, so that the pesticide containing box can be effectively protected; and the pesticide containing box can be effectively protected when the pesticide containing box fallsdown, and the pesticide containing box is not easy to damage.