The invention discloses a human body model applied to ECMO simulation practical training, which comprises a model main body and a simulated heart container arranged on the model main body, the simulated heart container is provided with a main venous canal and an aortic canal, and the model main body is provided with a femoral venous canal, a femoral artery canal, a jugular venous canal and a carotid artery canal. The upper end of the femoral vein tube, the lower end of the jugular vein tube and the main vein tube are connected through a three-way valve, the upper end of the femoral artery tube, the lower end of the carotid artery tube and the aorta tube are connected through a three-way valve, and the upper end of the jugular vein tube, the lower end of the femoral vein tube, the upper end of the carotid artery tube and the lower end of the femoral vein tube are all detachably connected with needle inserting tubes. According to the human body model, students can master clinical operation of ECMO skillfully, and meanwhile, a punctured tube can be replaced conveniently.