The invention discloses an IPFC-containing power system power flow optimization method based on MISOCP. The method comprises the following steps: S1, carrying out mathematical deformation and variablesubstitution of an IPFC conventional injection model, and building an IPFC model; S2, carrying out IPFC equality constraint convexity processing; S3, carrying out IPFC inequality constraint convexityprocessing; S4, adding a convex IPFC constraint into a linearized power flow optimization model; S5, carrying out MATLAB/GUROBI optimization calculation; and S6, according to an optimization result,obtaining an amplitude and a phase angle of an output voltage of the converter through reverse derivation. According to the IPFC-containing power system power flow optimization method based on the MISOCP, by utilizing mathematical deformation, approximate processing and binary expansion technologies, the convexity processing of an IPFC model is realized, a highly non-convex nonlinear optimizationproblem is converted into the MISOCP model, the model is high in solving speed, and a solution has global optimality. The method can accurately, efficiently and quickly complete the calculation of thepower flow optimization of the power system, is higher in practical value, and can provide theoretical and technical support for the online optimization and regulation of comprehensive FACTS.